Many commonly available plants like Leonatisleptiifolia, various species of Ficus like Ficus benghalensis, Ficus religiosa etc showed potent anthelmintic activity. The present study was aimed to compare the potencies of various parts of Ficus carica against earth worms as they anatomically resemble the round worms which cause helmenthiasis. Methanolic extract of leaves, stems and fruits of Ficus carica were compared for their in-vitro anthelmintic activity in order to determine the potencies of them. Results revealed that exposure of worms to leaf extract of F.carica takes 2-3 hr to cause paralysis and death of worms with  various concentrations of (20,30,40 mcg/ml). The stem extract of F.carica shows almost equal effect with 3hrs of exposure. While the methanolic fruit extract of F.carica is effective at more than 3 hrs of exposure. The results were compared with mebendazole as a positive control and normal saline as a negative control. Mebendazole shows 100% effective on exposure, while worms exposed to normal saline were still alive even after 3hrs of exposure.

Keywords: Ficus benghalensis, helmenthiasis, Mebendazole, earth worms.

1. Ryabokone v., onishchenko, the detailed description on heiminthiasis disease, isnc, 2013
2. Gordon MC, David JN. Natural product drug discovery in the next Millennium, Pharmaceutical Biology, 2001, 39: 8-17.
3. Antibacterial activity of Ficuscarica L. extract against six bacterial strains Hiba Hazim Hamid Al-Yousuf*
4. Methanolic Extract of Ficuscarica Linn. leaves exerts Antiangiogenesis Effects Based on the Rat Air Pouch Model of Inflammation Tahereh Eteraf-Oskouei, Saeideh Allahyari, Arezu Akbarzadeh-Atashkhosrow, Abbas Delazar, Mahdiyeh Pashaii, Siew Hua Gan, and Moslem Najafi
5. Anticancer Activity of Methanol Extract of Ficuscarica Leaves and Fruits Against Proliferation, Apoptosis, and Necrosis in Huh7it Cellsby Risa Purnamasari, Dwi Winarni, Adita Ayu Permanasari, Eva Agustina, Suhailah Hayaza, and Win Darmanto
6. h. chandrashekar, k.p. latha article, anthelmintic activity , department of chemisty,2008
7. snehal r adsul, patilh.s, method for anthelmintic activity on earthworms, journal of Pharmaceutical research,2013
8. Ficuscarica L. (Moraceae): Phytochemistry, Traditional Uses and Biological Activities Shukranul Mawa, Khairana Husain, and Ibrahim Jantan.
9. Evaluation of anthelmenthic activity of Carica papaya latex using pheritima posthuma lakshmikantha kanthal, prasenjitmondal, somnath de, sidhabathunianeela, satyavathi, Samuel george.
10. Devi rajeshwari, plants showing anthelmenthic activity, research journal of phytochemistry, 2014.
11. Determination of Anthelmintic Activity of the Leaf and Bark Extract of Tamarindus Indica LinnS. S. Das,1 Monalisha Dey, and A. K. Ghosh2,*

Sudheshna Loka

Assistant Professor, Gland Institute of Pharmaceutical Sciences, Shangrila Farms, Kothapet, Medakdist