Title: A study of role of Insulin resistance in recently detected hypertensives in a rural population of Kishanganj, Bihar-A Cross sectional observational study
Authors: Dr Sourav Chattopadhyay, Dr Aniket Sinha, Dr Suman Kumar Singh, Dr Sumit Singh Kaushal, Dr Abhinav Chaudhary, Dr Sandeep Bharadwaj
DOI: https://dx.doi.org/10.18535/jmscr/v9i10.31
Abstract
Introduction
Insulin resistance and compensatory hyperinsulinaemia commonly occur in patients with untreated essential hypertension. The coexistence of insulin resistance and hypertension can be viewed as a cause-effect relationship (insulin resistance as a cause of hypertension or vice versa) or as a noncausal association. Insulin can increase blood pressure via several mechanisms: increased renal sodium reabsorption, activation of the sympathetic nervous system, alteration of transmembrane ion transport, and hypertrophy of resistance vessels. Conversely, hypertension can cause insulin resistance by altering the delivery of insulin and glucose to skeletal muscle cells, resulting in impaired glucose uptake.(1)
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