Title: Dual malignancies: A Clinico Pathological study in a Regional Cancer Centre of North East India
Authors: Sobita D. Yumkhaibam, Sunita D. Akoijam, James L. Chongthu, Deiwakor Chyrmang and Kishalay Baidya
DOI: https://dx.doi.org/10.18535/jmscr/v9i9.26
Abstract
Introduction: Incidence of multiple primaries is increasing on account of exposure to common carcinogen, inherent genetic predisposition and increasing surveillance of cancer survivors.
Materials and Methods: This was a retrospective study of 48 patients with histologically proven double malignancy attending OPD at RCC, Imphal Manipur during a period 2015 to 2019. We had categorized the malignancies as synchronous if the interval between the first and second malignancy was 6 months or less and metachronous if interval was more than 6 months. Cases in whom the possibility of the second malignancy being metastatic deposit from first primary which was not completely ruled out were excluded.
Results: Out of forty-eight dual malignancies twenty-nine were synchronous and nineteen were metachronous. Most common first cancer was head and neck cancer and most common second cancer was gastrointestinal cancers.
Conclusion: Thorough evaluation of patients presenting with a primary malignancy and long-term surveillance of cancer survivors should be emphasized in view of increasing incidence of synchronous and metachronous malignancy.
Keywords: Clinicopathological study, dual malignancy, metachronous, synchronous.
References
- Xu LL, Gu KS. Clinical retrospective analysis of cases with multiple primary malignant neoplasms. Genet Mol Res.2014;13:9271-84.
- Moertel CG. Multiple primary malignant neoplasms: Historical perspectives. Cancer.1977;40:1786-92.
- Ferlay J, Steliarova- Foucher E, Lortet- TieulentJ, Rosso S, Coebergh JW, Comber H, et al. Cancer incidence and mortality patterns in Europe:estimates for 40 countries in 2012. Eur J Cancer.2013;49:1374-403.
- Vogt A, Schmid S, Heinimann K, Frick H, Herrmann C, Cerny T, et al. Multiple primary tumours: challenges and approaches, a review. ESMO Open 2017;2:e000172.doi:10.1136/esmoopen-2017-000172.
- Campbell LV Jr., Watne AL. Multiple primary malignant neoplasms. Arch Surg.1969;99:401-5.
- Ng AK, Kenney LB, Gilbert ES, Travis LB. Secondary malignancies across age spectrum. Semin Radiat Oncol. 2010;20:67-78.
- Eng C, Clayton D, Schuffenecker I, Lenoir G, Cote G, Gagel RF et al. The relationship between specific RET proto- oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis. JAMA.1996;276:1575-9.
- Meadows AT, Friedman DL, Neglia JP, Mertens AC, Donaldson SS, Stovall M,et al. Second neoplasms in survivors of childhood Cancer: Findings from the Childhood Cancer Survivor Study Cohort. J Clin Oncol.2009;27:2356-62.
- Jeremic B, Shibamoto Y, Acimovic L, Nikolic N, Dagovit A, Aleksandrovic J, et al. Second cancers occurring in patients with early non small cell lung cancer treated with chest radiotherapy alone. J Clin Oncol.2001;19:1056-63.
- Morris LG, Sikora AG, Hayes RB, Patel SG, Ganly I. Anatomic sites at elevated risk of second primary cancer after an index head and neck cancer. Canc Causes contr.2011;22:671-9.