The largest population in the world is suffered from diabetes mellitus type 2 which are characterized by hyperglycemia associated with minor and major complications and it is caused by acquired deficiency in production of insulin by the pancreas, or by the resistance of the insulin. The experimental study includes the acute oral toxicity study, OGTT and antidiabetic effect of Vidangadi Kvatha in STZ-Nicotinamide induced diabetes in rats. Oral Glucose Tolerance Test (OGTT) was performed in normal rats and results shows that 200 mg/kg reduces the blood glucose level 89.45±1.24 mg/dl in 2 hrs. The 100 mg/kg of Vidangadi Kvatha reduces the blood glucose level 93.34±2.25 mg/dl. Oral Glucose Tolerance Test (OGTT) in diabetic rat shows that 200 mg/kg dose of Vidangadi Kvatha lowers the blood glucose level 123.46±2.74 mg/dl in 2 hrs. Diabetic control rats shows blood glucose level 405.98±2.33 mg/dl and Glibenclamide 4 mg/kg lowers blood glucose level up to 98.42±3.14 mg/dl. In STZ-NAD induced diabetic rats Vidangadi Kvatha lowers the post prandial blood glucose level, SGOT, SGPT, Lipid profile and C-Peptide level. The study found that Vidangadi Kvatha have antidiabetic property.

Keywords: Diabetes Mellitus, Streptozotocin, Nicotinamide, OGTT, Vidangadi Kvatha, Glibenclamide, Gliclazide.

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Minshu Prashant

Department of Dravyaguna, IMS, Banaras Hindu University Varanasi India