Abstract
Background: Breast carcinoma is an epithelial malignancy and it is hormone dependent mostly. Breast carcinoma is the most frequently diagnosed malignancy among the women of all ages worldwide. In 2012, breast carcinoma was found to be the most common malignancy amongst women in India, way ahead of cervical cancer1,2. In the year 2020 the diagnosed cases of breast carcinoma among women were 22,61,419 3. Recently it has been documented that tumor progression is promoted by interaction of tumor cells with their microenvironment especially stromal cells. This understanding has brought forth new potential candidate markers like CD10. The aim of this study is to understand the Association of Stromal CD10 expression with ER, PR, HER-2/NEU, in IDC breast.
Methods: Fifty one cases of IDC, breast received as a specimen of modified radical mastectomy in Deptt of Pathology. IHC was done for ER, PR, Her-2/neu and CD10.
Results: Out of fifty one cases of IDC, stromal CD 10 positivity was seen in 84.3% of cases .ER and PR positivity was seen in 60.8% and 54.9% respectively. However HER-2/neu overexpression was observed only in 21.4% cases.
Conclusions: In majority of the cases of IDC, the tumor cells were positive for ER and PR. Her-2/neu was positive (score 3+) in only 21.6% of cases of IDC. Although majority (84.3%) of the cases of IDC showed stromal CD10 positivity, no statistical significant correlation was observed between stromal CD 10 expression and other IHC markers i.e ER , PR and HER-2/NEU in the cases of IDC breast in our study.
References
- Ganesh N. Sharma, Rahul Dave and K. K Sharma Cancer-Its various types along with causes, symptoms, treatments and stages, in: cancer info guide. 2009.
- Ghoncheh M, Momenimovahed Z, Salehiniya H. Epidemiology, Incidence and Mortality of Breast Cancer in Asia. Asian Pac J Cancer Prev. 2016;17(S3):47-52. doi: 10.7314/apjcp.2016.17. s3.47. PMID: 27165207.
- GLOBOCAN 2020, INTERNATION JOURNAL OF CANCER; November 2020.
- Hala N Hosni, M. D. Ahmed, ABD EL Aziz,M. D. ; Sahara A. Tabak,M. D and Maha Elsayed; Immunohistochemical study of stromal CD10 expression in Mammary duct carcinoma. Med J. Cairo Univ, 2012; 80,No 2:37-44.
- Premalatha;Analysis of CD10 Expression in Breast Carcinoma in Post Menopausal Patients. “IOSR Journal of Dental and Medical Sciences(IOSr-JDMS)16.7(2017);71-74.
- Jana SH, Jha BM, Patel C, Jana D, Agarwal A. CD10-A new prognostic stromal marker in breast carcinoma, its utility, limitations and role in breast cancer pathogenesis. Indian J Pathol Microbiol 2014;57:530-6.
- John S Meyer, Consuelo Alvarez, Clara Milikowski, Neal Olson,Irma Russo, Jose Russo,Andrew Glass, A Zehnbauer, Karen Lister, Reza Parwaresch. Breast carcinoma malignancy grading by Bloom – Richardson system vs proliferation index: reproducibility of grade and advantages of proliferation index. Moderen Pathology 2005;18:1067-1078.
- Louhichi T., Saad, H. , Dhiab, M. B. et al. Stromal CD10 expression in breast cancer correlates with tumor invasion and cancer stem cell phenotype. BMC Cancer18, 49 (2018). https://doi. org/10.1186/s12885-017-3951-8
- Kaur M, Kaur H, Manjari M, Vikrant Rai, Kiranjot Kaur. Assessment of clinical parameters and histopathological grading of breast cancer. International Journal of Contemporary Medical Research 2016;3 (10);2938-2941.
- Moritani S, Kushima R, Sugihara H, Bamba M, Kobayashi TK, Hattori T Mod Pathol. (2002) Apr;15(4):397-405.
- Breasted JH, editor. The Edwin Smith Surgical papyrus. Chicago, Illinois: The University Chicago Press; 1930. special edition, 1984
- Grossing of Surgical Oncology Specimens. Department of Pathology, Tata Memorial Hospital.2011:56-69.
- V Anuradha Devi, S. Chandra Sekhar, C. Saritha, S. Sanhya Anil, H. Sandhya Rani. A study on stromal CD10 expression in invasive breast carcinoma. IAIM, 2016;3(6):142-147.
- Block GE, Jensen EV, Polley TZ. The prediction of hormonal dependency of mammary cancer. Ann Surg. 1978; 182:342-52.
- Hutchinson WB, Thomas DB, Hamlin WB, et al. Risk of breast cancer in women with benign breast disease. J Natl Cancer Inst 1980;65:13-20.
- Taghizadeh-Kermani A, Jafarian AH, Ashabyamin R, Seilanian-Toosi M, Pourali L,Asadi M, Mashhadi L. The Stromal Overexpression of CD10 in Invasive Breast Cancer and its Association with Clinicopathologi Factors. Iran J Cancer Prev.2014;7(1):17-21.
- Alla H Raziq, Sarah M Masoud. The correlation of stromal Cd10 expression in invasive breast cancer with various clinicopathological parameters. Iraqi J. Comm. Med 2017;3:129-135.
- Puri V, Jain Manjula & Thomas, Shaji. (2011). Stromal Expression of CD10 in Invasive Breast Carcinoma and Its Correlation with ER, PR, HER2-neu, and Ki67. International journal of breast cancer. 2011.
- Mohammadizadeh F, Salavati M, Afshar Moghaddam N. CD10 expression in stromal component of invasive breast carcinoma: A potential prognostic determinant. J Res Med Sci 2012; 17(Spec 2):S 194-9.
Corresponding Author
Dr Ishant Sharma
JR, III Year, Deptt of Pathology, IGMC, Shimla