Background: Mean platelet volume (MPV) and inflammatory markers are affected in chronic inflammatory diseases. In this study we aimed to investigate the correlation of MPV with disease activity in patients with IBD: Ulcerative Colitis based on the UCEIS score.  The UCEIS consists of the following three descriptors and was calculated as a simple sum: vascular pattern (scored 0–2); bleeding (scored 0–3); and erosions and ulcers (scored 0–3). Therefore, the range of UCEIS scores is 0–8.

Materials and Methods: A total of 120 subjects were enrolled. The study group consisted of 40 patients with Ulcerative Colitis and the control group included 80 healthy subjects. Groups were compared regarding MPV and disease activity score - UCEIS.

Results: Groups were similar in terms of age, sex (p=0.23, 0.43, respectively). MPV levels were higher in patients with UC patients 9.71 compared to the controls 11.27  (p= 0.02). A significant correlation was found between MPV and UCEIS Score in patients.

Conclusion: MPV was found to be decreased in patients with IBD compared to the controls and there is a negative correlation with disease activity indices.

1. Öztürk ZA, Dag MS, Kuyumcu ME, Cam H, Yesil Y, Yilmaz N, et al. Could platelet indices be new biomarkers for inflammatory bowel diseases? Eur Rev Med Pharmacol Sci. 2013;17(3):334-41.
2. Talstad I, Rootwelt K, Gjone E. Thrombocytosis in ulcerative colitis and Crohn’s disease. Scand J Gastroenterol 1973;8: 135–8
3. Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis. 1996; 7(2):157-61.
4. Öztürk ZA, Dag MS, Kuyumcu ME, Cam H, Yesil Y, Yilmaz N, et al. Could platelet indices be new biomarkers for inflammatory bowel diseases? Eur Rev Med Pharmacol Sci. 2013;17(3):334-41.
5. Clarke K, Sagunarthy R, Kansal S. RDW as an Additional Marker in Inflammatory Bowel Disease/Undifferentiated Colitis. Dig Dis Sci. 2008;53(9):2521-3.
6. Danese S, Motte Cde L, Fiocchi C. Platelets in inflammatory bowel disease: clinical, pathogenic, and therapeutic implications. Am J Gastroenterol. 2004;99(5):938-45.
7. Travis SP, Schnell D, Krzeski P, et al. Developing an instrument to assess the endoscopic severity of ulcerative colitis: the Ulcerative Colitis Endoscopic Index of Severity (UCEIS). Gut 2012;61:535–542.
8. Peyrin-Biroulet L, Pane´s J, Sandborn WJ, et al. Defining Disease Severity in Inflammatory Bowel Diseases: Current and Future Directions. Clin Gastroenterol Hepatol 2016;14(3):348–54.e17.
9. Lewis JD. The utility of biomarkers in the diagnosis and therapy of inflammatory bowel disease. Gastroenterology 2011;140(6):1817–26.e2.
10. Semple JW, Italiano JE, Freedman J. Platelets and the im­mune continuum. Nat Rev Immunol 2011;11(4):264-74. doi: 10.1038/nri2956.
11. Schoepfer AM, Beglinger C, Straumann A, et al. Fecal calprotectin more accurately reflects endoscopic activity of ulcerative colitis than the lichtiger index, C-reactive protein, platelets, hemoglobin, and blood leukocytes. Inflamm Bowel Dis 2013;19(2):332–41.
12. Camitta BM, Slye RJ. Optimizing Use of the Complete Blood Count PediatriaPolska 2012;87(1):72-7.
13. Kamath S, Blann AD, Lip GY. Platelet activation: assessment and quantification. Eur Heart J. 2001;22(17):1561-71.
14. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD: Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 2011, 17:47–58.Danese S, Motte Cde L, Fiocchi C. Platelets in inflammatory bowel disease: clinical, pathogenic, and therapeutic implications. Am J Gastroenterol. 2004;99(5):938-45.
15. Mustafa Guclu, HakanSakallı, TolgaYakar. Mean Platelet Volume may be Reflects the Disease Activity of Ulcerative Colitis. Eur J Gen Med 2010; 7: 259-263
16. Kapsoritakis AN, Koukourakis MI, Sfiridaki A, PotamianosSP, Kosmadaki MG, Koutroubakis IE, Kouroumalis EA.Mean platelet volume: a useful marker of inflammatory bowel disease activity. Am J Gastroenterol 2001; 96: 776-781
17. Levin, G., Popovicheva, A.N., Sosnina, L., Fedulova, E.N., &Sheremet’ev, Y.A. (2018). Mean Red Cell and Platelet Volume and Blood Cells Aggregation in Children with Inflammatory Bowel Diseases.
18. Saler, T., ÖzgürKeşkek, Ş., Ergin, C., Ahbab, S. and Sağlam, Z., 2016. Mean platelet volume in patients with inflammatory bowel disease. General Internal Medicine and Clinical Innovations, 1(3), pp.40-43.
19. Liu S, Ren J, Han G, Wang G, Gu G, Xia Q, Li J. Mean platelet volume: a controversial marker of disease activity in Crohn’s disease. Eur J Med Res 2012; 17: 27
20. Deutschmann A, Schlagenhauf A, Leschnik B, Hoffmann KM, Hauer A, Muntean W. Increased procoagulant function of microparticles in pediatric inflammatory bowel disease: role in increased thrombin generation. J Pediatr Gastroenterol Nutr. 2013;56(4):401-7.
21. Preston RA, Jy W, Jimenez JJ, Mauro LM, Horstman LL, Valle M, et al. Effects of severe hypertension on endothelial and platelet microparticles. Hypertension. 2003;41(2):211-7.

Anuvind T

Institute of Medical Gastroenterology, Madras Medical College, The Tamil Nadu Dr. M.G.R Medical University, Chennai, Tamil Nadu, India