Title: A Prospective Study on Maternal and Fetal outcome in Jaundice complicating Pregnancy
Author: Lavanya.S.S
DOI: https://dx.doi.org/10.18535/jmscr/v9i1.10
Abstract
Introduction
Hepatobiliary disorders that occur during pregnancy can be a clinical challenge .During pregnancy the hemodynamic, hormonal and immunological changes alter the course of both acute and chronic liver diseases .Hepatic disorders complicate about 3% of all pregnancies. Certain hepatic disorders like hyperemesis, Acute Fatty Liver of pregnancy, Intrahepatic cholestasis of pregnancy and HELLP syndrome are unique to pregnancy. Pre existing liver diseases like viral hepatitis, cirrhosis and portal hypertension and Wilson’s disease can have an impact on pregnancy.
AFLP is an obstetric emergency that can lead to fulminant hepatic failure. It is associated with fatty infiltration of heptocytes without inflammation or necrosis. Maternal genetic mutation affects mitochondrial fatty acid oxidation leading to fetal deficiency of the enzyme Long chain 3-hydroxyacyl-CoA dehydrogenase. This results in deposition of long chain fatty acids in maternal liver and leads to impaired hepatic function.
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