Title: Study of Mean Platelet Volume in Acute Coronary Syndrome
Authors: Prasanth Kumar P, Ramakrishna Rao, Periasamy S
DOI: https://dx.doi.org/10.18535/jmscr/v8i11.63
Abstract
Background: As the initial step in pathogenesis of Acute coronary syndrome is plaque erosion, rupture and thrombus formation. Mean platelet volume (MPV) correlates with platelet function and activation. Mean platelet volume can be used as a diagnostic parameter in patients with Acute Coronary syndrome. The primary objective of this study is to find out the association between mean platelet volume and Acute Coronary syndrome.
Methods: Our study included 50 cases with acute coronary syndrome and 50 controls who were selected based on inclusion and exclusion criteria. Mean platelet volume estimated by auto-analyser is compared between ST-elevation Myocardial infarction, Non- ST-elevation Myocardial infarction and control group.
Results: The mean value of mean platelet volume among those with diagnosis STEMI, NSTEMI and CONTROL was 11.09 ± 1.046 fl, 10.5 ± 0.54fl, and 7.84 ± 0.375 fl respectively. The mean was found to be statistically significant for each diagnosis.
Conclusion: Our study concluded that mean platelet volume is higher in patients with STEMI than NSTEMI but in control group mean platelet volume found to be normal .Hence mean platelet volume can be used as a diagnostic marker in Acute coronary syndrome.
Keywords: Acute coronary syndrome, STEMI, NSTEMI, Mean platelet volume.
References
- Endler G, Klimesch A, Sunder-Plassmann H, Schillinger M, Exner M, Mannhalter C, et al. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br. J. Haematol., 2002
- Furie B, Furie BC. Mechanism of thrombus formation.N Engl J med 2008;359(9):938-49.
- Thompson CB, Jakubowski JA, Quinn PG, et al. Platelet size as a determinant of platelet function. J Lab Clin Med 1981;101(2):205-213.
- Corash L.The relationship between megakaryocyte ploidy and platelet volume.Blood cells 1989 ;15:81.
- Paulus JM. platelet size in man. Blood 1975;46:321
- Pal R, Bagarhatta R, Gulati S, Rathore M, Sharma N. Mean platelet volume in acute coronary syndrome. JCDR. 2014;8(8):1-4.
- Pervin S, Ferdousy S, Hossain M, Joarder AI, Sultana T. Elevated mean platelet volume is a marker of acute coronary syndrome. Bangladesh Med J. 2013;42 (2);45-50.
- Mathur A, Robinson MS, Cotton J, Martin JF, Erusalimsky JD. Platelet reactivity in acute coronary syndromes: evidence for differences in platelet behaviour between unstable angina and myocardial infarction. Thrombosis and Haemostasis. 2001;85: 989-94.
- Assiri AS, Jamil AM, Mahfouz AA, Mahmoud AS, Ghallab S. Diagnostic importance of platelet parameters in patients with acute coronary syndrome admitted to a tertiary care hospital in southwest region, Saudi Arabia, J Saudi Heart Assoc. 2012;24(1):17-21.
- Ulusoy RE, Yokuşoğlu M, Kırılmaz A, Nevruz O, Baysan O, Kılıçaslan F, et al. Mean platelet volume in ST elevation and non-ST elevation myocardial infarction. Gulhane Med J. 2011; 53(2):114-8.