Title: A Study on Abnormalities of Lipid Profile in relation to primary open angle glaucoma in type-2 Diabetes mellitus
Authors: Ankit Kumar Tiwari, Shreya Nigoskar, Sonalee Mittal, Suresh Babu Kondaveeti
DOI: https://dx.doi.org/10.18535/jmscr/v8i11.62
Abstract
Introduction: In developing countries like INDIA the prime source of irrevocable visual impairment mainly because of an age related chronic disorder Primary open-angle glaucoma (POAG). It is well known that POAG associated with Type 2 diabetes and hypertension patients.
Aim and Objective: This study aimed to assess the biochemical study in Type-2 Diabetes mellitus primary open angle glaucoma patients as compared to normal controls.
Material and Methods: A total of 200 patients, 100 Type-2 Diabetes mellitus Primary open-angle glaucoma patients with Diabetes and 100 diabetes without POAG from the last one year and 100 normal healthy individuals were chosen as a control group.
Results: The mean values of FBS, HbA1c were significantly increased (P<0.0001) in type -2 Diabetes mellitus Primary open-angle glaucoma cases as compared to normal healthy individuals. Other mean values TC, TG, LDL significantly increased (P<0.0001) in type -2 Diabetes mellitus Primary open-angle glaucoma patient as compared to controls. Whereas the mean value of HDL was significantly decreased in type -2 Diabetes mellitus Primary open-angle glaucoma patient as compared to controls.
Keywords: Primary open-angle glaucoma, FBS, HbA1c, and lipid profile, Type – 2 diabetes mellitus.
References
- Coleman A.L., Brigatti L. The glaucomas.Minerva Med.2001;92(5):365–379
- Izzotti A, Bagnis A, Saccà SC. The role of oxidative stress in glaucoma. Mutat Res. 2006;612:105–14.
- Ferreira SM, Lerner SF, Brunzini R, Evelson PA, Llesuy SF. Oxidative stress markers in aqueous humor of glaucoma Patients. Am J Ophthalmol. 2004;137:62–9.
- Feilchenfeld Z, Yücel YH, Gupta N. Oxidative injury to blood vessels and glia of the pre-laminar optic nerve head in human glaucoma. Exp Eye Res. 2008; 87:409–14.
- Dube M, Chhawania PK, Shukla A, Kujur R, Correlation Between Serum Lipids and Primary Open Angle Glaucoma: A Clinical Study D. J. Ophth. 2019; (5):58-60DOI:http://dx.doi.org/10.7869/djo.444
- Wierzbowska J, Figurska M, Stankiewicz A, Sierdzinski J. Risk factors in age-related macular degeneration and glaucoma–own observations. KlinOczna 2008; 110:370-4.
- Gupta R, Sharma A, Sharma HR, Dyslipidemia in Primary Open Angle Glaucoma. JK SCIENCE; 2020;2 ( 22): 84-87.
- Trinder P., Annals. Clin. Biochem. 6, L4 (1969).
- Stein E.A. and Myers G.L. “Lipids, lipoproteins and apolipoproteins” in Tietz Textbook of clinical chemistry. Burtis C.A. and Ashwood E.R. (Ed). WB Saunders Company, second edition. 1994; 23:100-93.
- Richmond, W., Clin. Chem. 19., 1350 (1973).
- Gordon, T., et al.: Am. J. Med. 62, 707 (1977).
- Seiichiro Tarui: Ministry of Health and Welfare Primary Hyperlipidemia Research Committee, 1986 Annual Report (Committee Leader: Seiichiro Tarui), P17-26, 1987.
- Hazari NR, Hazari AR. Relationship of fasting blood glucose and HbA1c with IOP in primary open angle glaucoma patients. BCAIJ, 2015; 9(5):169-173.
- Reddy M, Malleswari M, Sai Rani K, Prevalence of Primary Open Angle Glaucoma in Diabetic Patients. IOSR-JDMS; 2017; 6(16): 147-151 DOI: 10.9790/0853-160603147151.
- Channabasappa S, Sanjana S, Mirdehghan MS. A study to evaluate the intraocular pressure variations in type 2 diabetes mellitus. Int J Health Sci Res. 2016; 6(5):60-64.
- Pavljasevic S, and Asceric M, Primary open-angle glaucoma and serum lipids.Bosn J Basic Med Sci.2009; 9(1):85–88.
- Raffaella MB, Cillino S. The Role of Plasma Lipid Profile in Patients with Type A Behavior Pattern with POAG. J. Ophth. Res. 2018; 4(1): 268-271.
- Desai A, Patel D, Sapovadia A, Mehta P, Brahmbhatt J,A study of relation between primary open angle glaucoma and type II diabetes mellitus.Int J Res Med Sci. 2018;6(3):997-1001.