Title: Prognostic Value of Serum Acetylcholinesterase Levels in Acute Organophosphorus Poisoning: Study from an Intensive Care Unit at a Tertiary Care Teaching Hospital of North India
Authors: Ruksana Hamid, Rayees ul Hamid Wani, Abdul Qayoom lone, Suhail Sidiq, Mohammad Akbar Shah, Abdul Waheed Mir
DOI: https://dx.doi.org/10.18535/jmscr/v8i11.51
Abstract
Introduction: Organophosphorus poisoningis of great concern in developing world as it affects the most productive age group of the society and has a high case fatality rate.
Objective: To assess the role of Serum acetylcholinesterase Levels in predicting morbidity and mortality in Acute Organophosphorus Poisoning.
Methodology: A prospective two year study was conducted to evaluate the possible impact of serum acetylcholinesterase levels on mortality and morbidity of patients admitted in ICU with diagnosis of Acute organophosphorus poisoning.
Results: A total of 102 cases were studied. The study revealed that the patients with serum acetylcholinesterase level <2300 IU/l at presentation have greater morbidity and the patients with serum acetylcholinesterase level <1800 IU/l at presentation have greater mortality.
Conclusion: It can be suggested that the serum acetylcholinesterase levels can be used to predict mortality and morbidity in low resource settings of developing world.
Keywords: Organophosphorus, Prognosis, Poisoning, Acetylcholinesterase.
References
- Suhail Sidiq et al.A Study of Possible Prognostic Predictors of Organophosphorus Poisoning International Journal of Medical Science and Current Research (IJMSCR) Volume 2, Issue 2; March-April 2019; Page No. 32-39.
- Jeyaratnam J. Acute pesticide poisoning: A major global health problem. World Health Stat Q 1990; 43:139-44.
- Yang CC, Deng JF. Intermediate syndrome following organophosphate insecticide poisoning. J Chin Med Assoc 2007;70:467-72.
- Yanagisawa N, Morita H, Nakajima T. Sarin experiences in Japan: Acute toxicity and long-term effects. J Neurol Sci 2006; 249:76-85.
- Wadia RS. Treatment of organophosphate poisoning. Indian J Crit Care Med 2003; 17 : 85-7.
- Singh S, Chaudhry D, Behera D, Gupta D, Jindal SK. Aggressive atropinization and continuous pralidoxime infusion in patients with severe organophosphate poisoning : Experience of northwest Indian hospital. Him Exp Toxicol 2004; 23: 565-9.
- Raddi D, Anikethana G. Liver Enzymes for Assessment of Severity of Organophosphorus Poisoning. Int J Med Health Sci. Jan 2015, Vol-4;1: 60-63.
- Rehiman S, Lohani SP, Bhattaria MD. Correlation of serum cholinesterase level, clinical score at presentation and severity of organophosphorus poisoning . J Nepal Med Assos, 2008;47(170): 47-52.
- Kang EJ, Seok SJ, Lee KH, Gil HW, Yang JO, Lee EY et al. Factors for determining survival in acute organophosphate poisoning. The Korean journal of internal medicine, 2009; 24(4).
- Many MS, prashant V, Akila P,Sums MN, Bass an a good apps H. A retrospective analysis of serial measurement of serum cholinesterase in acute poisoning with organophosphate compounds. Toxicol Into, 2012;19: 255-9.
- Banday TH, Tathineni B, Desai MS, Naik V. Predictors of morbidity and mortality in organophosphorus poisoning: A case study in a rural hospital in Karnataka , India. North American journal of medical sciences June 2015; 7(6): 259-265.