Title: A Rare Case of Acute Paraplegia: Granulocytic Sarcoma- Case Report
Authors: Dr Dhivya C, Dr Aswinth M.D.
DOI: https://dx.doi.org/10.18535/jmscr/v8i11.43
Abstract
Granulocytic sarcoma (GS) or also known as choloroma, myeloblastoma, myelosarcoma, is an uncommen extramedullary solid tumor of immature myeloid cells. The term ‘chloroma’ was given by King due to the green appearance which is produced by the presence of myeloperoxidase granules in the malignant myeloid cells in 1853. It could occur in anywhere in the body, soft tissues or lymph node rarely involving central nervous system and leading to spinal cord compression, in association with AML. It could occur during the course of disease, or at relapse, or as isolated granulocytic sarcoma (IGS). We report a case of 18 years old boy presented with paraplegia, diagnosed as Granulocytic sarcoma associated with Acute Myeloid Leukemia.
References
- Hu X, Shahab I, Lieberman IH. Spinal Myeloid Sarcoma “Chloroma” Presenting as Cervical Radiculopathy: Case Report. Global Spine J. 2015; 5: 241-246.
- Karlin L, Itti E, Pautas C, Rachid M, Bories D, Cordonnier C, et al. “PET-imaging as a useful tool for early detection of the relapse site in the management of primary myeloid sarcoma”. Haematologica. 2006; 91: (12 Suppl): EcR54.
- Pileri SA, Ascani S, Cox MC, Campidelli C, Bacci F, Piccioli M, et al. Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. Leukemia. 2007; 21: 340-350.
- Seifert RP, Bulkeley W, Zhang L, Menes M, Bui MM. A practical approach to diagnose soft tissue myeloid sarcoma preceding or coinciding with acute myeloid leukemia. Ann Diagn Pathol. 2014; 18: 253-260.
- Seok J H, Park J, Kim S K, Choi J E, Kim C C. Granulocytic sarcoma of the spine: MRI and clinical review. AJR Am J Roentgenol. 2010; 194: 485-489.
- Campidelli C, Agostinelli C, Stitson R, Pileri SA. Myeloid sarcomextramedullary manifestation of myeloid disorders. Am J Clin Pathol. 2009; 132: 426-437.
- Cheah KL, Lim LC, Teong HH, Chua SH. A case of generalized cutaneous granulocytic sarcoma in an elderly patient with myelodysplastic syndrome. Singapore Med J. 2002; 43: 527-529.