Introduction: General anaesthesia is associated with marked cardiovascular changes. Induction with propofol is accompanied by decrease in mean blood pressure and heart rate. Ketamine and butorphenol provides stable perioperative hemodynamics during general anaesthesia.

Aims and Objectives: The aim of this study was to evaluate the efficacy of intravenous low dose ketamine with intravenous butorphanol on hemodynamic stability during laryngoscopy and intubation, intraoperative hemodynamics and postoperative pain.

Methods and Materials: It was a prospective randomised clinical study in which 100 ASA grade 1 or 2 patients who were posted for elective laparoscopic cholecystectomy under general anaesthesia, were enrolled into one of the two groups according to the agents to be given as an adjuvent for induction of general anaesthesia. Group A patients received 0.3mg/kg ketamine and group B patients received butorphanol 0.02mg/kg by intravenous route.

Conclusion: The present study observed excellent endotracheal intubation conditions with propofol and ketamine combination as compared to propofol and butorphanol combination. Analgesic effects of ketamine and butorphanol in the postoperative period were similar and helped painless shifting of patients.

Keywords: Butorphanol, Hemodynamic response, Endotracheal intubation, Ketamine, Laparoscopic cholecystectomy.

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Gopal Krishan

Associate Professor, Department of Anaesthesiology, RMCH Bareilly