Title: Stimulatory Influence of select Spices on Gastric Acid Secretion in Anaesthetized Wistar Rats
Authors: K. Vasudevan, T.Satesh, S.Manoharan
DOI: https://dx.doi.org/10.18535/jmscr/v8i9.47
Abstract
The effect of common food spices, Cumium cyminum (seeds) and Carum copticum on gastric acid secretion was studied in anesthetized adult male wistar rats. The rats were perfused with nomal Saline (control group) and 7.5% aqueous extract of fried Carum copticum and Cuminum Cyminum seeds (experimental groups 1 and 2). It was observed that during the period of 90 minutes perfusion with Carum copticum seed fried extract, the acid secretion ranged from 0.663 ± 0.037 to 1.605 ± 0.066 m Eq/lit and 0.662 ± 0.0241 to 1.196 ± 0.063 m Eq/lit in the case of Cuminum Cyminum (seeds). The gastric acid production in both experimental groups was higher when compared to control group perfused with normal saline, where the range of value lies between 0.234 ± 0.0085 to 0.367 ± 0.017 mEq/lit.. The experiment was therefore suggestive that both Carum copticum and Cuminum Cyminum seeds were effective gastric acid secretogogues, the effect being higher with Carum copticum.
Keywords: Gastric acidity, Gastric acid secretion, Carum copticum, Cuminum Cyminum, wistar rat.
References
- Almofleh, I.A, (2010), Spices, herbal xenobiotics and the stomach; Friends or foes? world Journal of Gastroenterology, 16 (22): 2710-2719.
- Devasankaraiah, G; Hanin, I; Haranath, P.S.R.K. and Ramanamurthy, P.S.V. (1974). Cholinomimetic effect of aqueous extracts from Carum copticum Br. J. Pharmacol. 52; p.613-614.
- Ghosh, M.N. and Schild, H.o. (1958) continuous recording of acid secretion in the rat. Br. J. Pharmacol. 13;p.54-61.
- Haranath, P.S.R.K.,; Akther M.H. and sharif, S.I. (1987). Acetylcholine and choline in common spices. Phytotherapy Reasearch 1 ; p. 91-92.
- Joseph, I., Silsa,T.V, Andefiki, U., Olang, O.J.,(2017) effect of ethanolic extracts of selected dietary spices on gastric acid secretion in Wistar rats. Intl. J chemical and Biomedical science.3(4): 32-38.
- Kirtikar, K.R. and Basu, B.D. (1984). Indian Medicinal plants second edn. 4 volumes. Publishers Bishen Singh Mahendra palsingh, Dehra Dun, India.
- Lizt, K.I., Ley, J.P., Lider, B., Behrens, M., Stoger, V., Reiner, A, Hochkogler, C.M., Kock, E., Marchiori, A., Hans, J., Widder.S., Krammer, G., Sager, G.J., Somoza, M.M., Meyerhof. W., Somoza, V., (2017), Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells. PNAS : E6260 - E6269. doi/10.1073/Pnas.1703728114.
- Nadkarni, A.K. (1976) Dr. K.M. Nadakarni’s Indian Materia Media. Popular Book depot, Bombay, India; 269-410.
- E/F/ (1989), Martindale. The extra pharmacopeia, 29th Edn. The pharmaceutical press, London, U.K.
- Vasudevan, K.; Vembar, S,; Veeraraghavan K. and Haranth, P.S.R.K. (2000), Influence of intragastric perfusion of aqueous spice extracts on acid secretion in anesthetized albino rats. Indian Journal of Gastroenterology 19; p. 53 – 56.