Background: Tuberculosis (TB) is a chronic infectious disease that has afflicted mankind for 5000 years. It has caused more deaths in adults than any other infectious disease The emergence of multidrug-resistant (MDR) TB has introduced challenging, but surmountable, complexities to TB programs, MDR-TB remains a public health crisis and a health security threat.. XDR-TB is more expensive and difficult to treat than MDR-TB and outcomes much worse with higher rates of treatment failure and death. Therefore we planned this study to analyze the various clinico socio demographic factors associated with the development of XDR-TB among MDR-TB patients

Objective

• To assess the various clinico socio demographic status of MDR cases
• To identify the associated factors for the conversion of MDR to XDR tuberculosis.
• To estimate the conversion rate of XDR tuberculosis from MDR tuberculosis

Method: It was a hospital based observational and prospective study. Informed consent of the patient was taken for the study. All information to accomplish objectives was collected by personal interview of each of the study subjects for about 30 to 45 minutes at PMDT site using pre-designed and pre-tested Proforma.

Results: Among the study participants 66.5%(125) were males and 33.5%(63) were females. Among males 16.8% (21) got converted to XDR while among the females 33.3%(21) converted to XDR tuberculosis. In the study 39.9% (75) were living in houses without overcrowding and 60.1%(113) were living in houses with overcrowding. . Among those living in overcrowded houses 14.7%(11) converted to XDR. In those who didn’t live in overcrowded houses 27.4%(31) converted to XDR.

Keywords: MDR-TB ,XDR-TB, clinico socio demographic impact, associated factors, conversion rate.

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Dr S.Hariharan

Junior Resident, Dept of Tuberculosis & Respiratory Medicine SN Medical College, Agra