Title: Association of dyslipidemia and Diabetic Retinopathy among patients coming to OPD of Katihar Medical College Hospital and its visual outcome: A prospective observational study
Authors: Dr Himanshu Kumar, Dr Arjun Kumar Singh
DOI: https://dx.doi.org/10.18535/jmscr/v8i6.70
Abstract
Introduction
Diabetic retinopathy (DR) is one of the major microvascular complications of diabetes. It is one of the most common cause of preventable blindness in diabetic adults. Dyslipidemia, a major systemic disorder, is one of the most important risk factors for cardiovascular disease. Patients with diabetes have an increased risk of suffering from dyslipidemia concurrently.
Aims and Objective of the study
- To find out the association between Diabetic Retinopathy (DR) and Lipid Profile.
- To find out the possible mechanisms involving lipid metabolism and diabetic retinopathy.
- To find out the effect of lipid-lowering therapies on diabetic retinopathy.
References
- Kulshrestha OP, Nayarand SK, Sharma DP. Role of serum lipids in diabetic retinopathy. Indian J Ophthalmol 1979; 27:116-118.
- J Idiculla, S Nithyanandam, M Joseph, VKA Mohan, U Vasu, M Sadiq. Serum lipids and diabetic retinopathy: a cross-sectional study. Indian J Endocrinol Metab 2012; 16(Suppl 2) :S492-S494.
- Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994; 331 :1480-1487.
- Sachdev N, Sahni A. Association of systemic risk factors with the severity of retinal hard exudates in a north Indian population with type 2 diabetes. J Postgrad Med 2010; 56 :3-6.
- Frank RN. Diabetic retinopathy. N Engl J Med 2004; 30 :451-457.
- Dornan TL, Carter RD, Bron A. Low density lipoprotein cholesterol: an association with the severity of diabetic retinopathy. Diabetologia 1982; 22 :167-170.
- Larsson LI, Alm A, Lithner F, Dahlen G, Bergstrom R. The association of hyperlipidemia with retinopathy in diabetic patients aged 15-50 years in the county of Umea. Acta Ophthalmol Scand 1999; 77 :585-591.
- Rema M, Srivastava BK, Anitha B, Deepa R, Mohan V. Association of serum lipids with diabetic retinopathy in urban south Indians - The Chennai Urban Rural Epidemiology Study (CURES) Eye Study-2. Diab Med 2005; 23 :1029-1036.
- OM Jew, M Peyman, TC Chen, S Visvaraja. Risk factors for clinically significant macular edema in a multi-ethnics population with type 2 diabetes. Int J Ophthalmol 2012; 5 :499-504.
- Told DR, Baratsits M, Garhöfe GR, Schmetterer L. Early Treatment Diabetic Retinopathy Study (ETDRS) diabetic retinopathy study design and research group and baseline patient characteristics. 1991; 98:741-756.32. Early Treatment Diabetic Retinopathy Study Report Number 7. ETDRS. Ophthalmology 1991; 98 :741-756.
- Klein BEK, Moss SE, Klein R, Surawicz TS. The Wisconsin Epidemiologic Study of Diabetic Retinopathy, XIII: relationship between serum cholesterol to retinopathy and hard exudate. Ophthalmology 1991; 98 :1261-1265.
- ACCORD Eye Study Group, Chew EY, Ambrosius WT, Davis MD, Danis RP, Gangaputra S, Greven CM, et al. Actions to Control Cardiovascular Risk in Diabetes (ACCORD) Study Group; Medical Therapies effects on retinopathy Progression in Type 2 diabetes. N Engl J Med 2010; 363 :233-244.
- Hadjadj S, Duly-Bouhanick B, Bekherraz A, Bridoux F, Gallois Y, Mauco G, et al. Serum triglycerides are predictive factor for the development and the progression of complications in patients with type 1 diabetes. Diabetes Metab 2004; 30 :43-51.