Hypothyroidism is a common metabolism disorder. In India, 42 million people are suffering from thyroid diseases. Hypothyroidism being a commonest metabolism disorder¹ (Unnikishnan AG and Menon UV, 2011). Wide arrays of functions are performed by the thyroid hormones such as regulation of lipid, carbohydrate, protein, electrolyte and mineral metabolism. The significant effect of thyroid hormones on synthesis, and metabolism of lipids leads to an alteration in the composition and transport of lipoprotein in thyroid disorders. The present study is undertaken to understand the association between the lipid profile and subclinical hypothyroidism’s The study was conducted for a period of six months in the Medicine Department, Government General Hospital, Vijayawada.  A total number of 100 subjects (50 cases and 50 controls) were selected for the present study. Inclusion Criteria: Cases- 50, newly diagnosed cases of hypothyroidism in the age group of 15 -75 years attending the department of medicine were included in the study. Controls- 50, age and sex matched healthy euthyroid subjects were selected. Serum lipid profile was analyzed by using analytical kits from ERBA diagnostics in semi-auto analyzer. Serum thyroid profile was estimated using ERBA thyrokit. ⁶LDL was calculated from Friede walds’ formula.

Results: There was no significant difference in the mean of free T3 levels of both the case and control groups. Mean T4 was lower in control in comparison with the case. Mean TSH in case was significantly higher than the controls. The mean total cholesterol levels were significantly higher in patients with hypothyroidism than in the controls. The mean HDL was lower in patients with hypothyroidism than in the controls. There was significant difference between the LDL mean values of case and control subjects. There was significant increase in VLDL levels of controls in comparison to case subjects. There was a significant difference in the TG levels between the case and controls.

Keywords: Hypothyroidism, LDL, HDL, TG, Cholesterol.

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Dr S.R. Manjula

Associate Professor, Department of Physiology, Siddhartha Medical College, Vijayawada, India