Introduction: Prostatic diseases are highly prevalent in men worldwide among which Prostate cancer (PCa) is a significant cause of morbidity and mortality especially in many western countries and second leading cause of death in India. Relationship between Prostate cancer, Precancer and obesity has been observed in previous studies, however it is unlikely in Indian scenario, but the possibility of its association with cytokines, lipids and androgens level derangement can’t be ignored. So, the study is planned to observe the association of metabolic outline, lipid and cytokines profiling, androgens, insulin in Precancer and in Prostate cancer risk and aggressiveness.

Material and Method: A cross-sectional study was conducted to observe the association of association of metabolic profile, lipid profile and levels of cytokines, androgens, insulin in PIN and PCa patients. 50 patients of PIN and 50 patients clinically proved and histologically diagnosed with prostate cancer were evaluated in the study.

Results: Association of Lipid profile, androgens levels and cytokines levels are significant in precancer and PCa. Leptin may potentiate the growth of cancer cells, adiponectin appears to have an opposite effect.

Conclusion: Adiponectin works as anticancer gene and leptin can potentiate the growth of prostate cancer. Cytokines (eg. leptin), lipids and androgens may serve as prognostic parameters for early detection of prostate cancer. This could lead to better understanding of the PCa and in future may help in improving clinical management of the patients.

Keywords: Cytokine, Androgens, Insulin, Precancer, Prostate cancer, Lipid Level, Lipid profile.

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Reshu Tewari