Introduction: Gastric disorders are one of the most commonly encountered problems in clinical practices. The definitive diagnosis of gastric disorders rest on histopathological confirmation and is one of the gold standard investigation for gastric lesions.

Materials and Methods: This prospective observational study of two years duration was carried out to determine the histopathological spectrum of gastric lesion in endoscopic biopsies at tertiary care center. Total 272 consecutive gastric biopsies were included in study.

Results: Neoplastic lesions accounted for 64.8% of cases outnumbering non-neoplastic lesions which constituted about 36.15% of cases. Chronic gastritis (68.09%) was the commonest non-neoplastic lesion. Helicobacter pylori positivity was seen in 61% cases of chronic gastritis. In the neoplastic category Adenocarcinoma of intestinal type was the commonest malignancy (98.7%) followed by signet ring carcinoma accounting for 20.13% of cases.

Conclusion: Upper GI endoscopy with biopsy helps in the evaluation of  chronic gastritis ,detection of Helicobacter  pylori, early diagnosis of cancer risk factors especially atrophy, intestinal Metaplasia and dysplasia ,distinguishes benign from malignant gastric ulcers and different types of gastric tumors thus providing wide range of treatment options and possible cure.

Keywords: Upper GI endoscopy, Gastric biopsy, Histomorphological spectrum.

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Dr Sanjay Parate

Department of Pathology, Government Medical College and Super Speciality Hospital, near Hanuman Nagar, Nagpur – 440009, Maharashtra India