Title: Correlation of Urine Cytology for Urothelial Carcinoma as per Paris System with Histopathology
Authors: Dr Aditya Jamwal, Dr Sudarshan Kumar Sharma, Dr Neelam Sharma, Dr Pamposh Raina, Dr Anjali Mahajan
DOI: https://dx.doi.org/10.18535/jmscr/v8i5.13
Abstract
Objectives: This study aims to evaluate the diagnostic accuracy of urine cytology for urothelial carcinomas as per the Paris System and its histopathological correlation.
Methods: A cross-sectional study was conducted over 1 year (July 2018 – June 2019). The study population comprised patients presenting with haematuria/dysuria and had radiological findings suggestive of bladder tumor. Preoperative, early morning, midstream, voided urine samples were collected and processed for three consecutive days. The cytospin smears were stained with Papanicolaou stain and reported as per the Paris system. These results were then correlated with gold standard test i.e. Histopathology of TURBT as per WHO classification 2016(4). Relevant statistical tests were utilized for data analysis.
Results: 40 cases were studied. According to the reporting criteria of the Paris System, 62.5% cases were positive for malignancy and 37.5% cases were negative for malignancy. On histopathology, 82.5% cases were positive for urothelial carcinoma and 17.5% cases were negative for urothelial carcinoma. The sensitivity of urine cytology was calculated to be 75%, specificity of urine cytology was 87.5% and the positive predictive value was 96%.
Conclusion: Urine Cytology as reported by the Paris System will lead to uniform and unequivocal reporting of urothelial carcinoma.
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