Background: Diabetes Mellitus refers to a group of metabolic disorder, characterised by high blood sugar and disturbance of carbohydrate, fat and protein metabolism due to absolute or relative deficiency of insulin secretion or insulin action or together. Both lipid profile and diabetes is predictors for metabolic disturbances including dyslipidaemia, hypertension, cardiovascular diseases. Lipids play a vital role in the pathogenesis of diabetes mellitus and dyslipidemia as a metabolic abnormality is frequently associated with it.

Methods: Study was conducted on 120 patients (62 males and 58 females) of age group 30 to 70 years of diagnosed type 2 Diabetes Mellitus. Lipid abnormality and relationship between different parameters like routine, blood sugar, HbA1C level and lipid profile in type 2 Diabetic Mellitus patients was done.

Study Period: January 2018 to October 2019.

Result: Study concluded that out of total study subject having t2dm about 80%) had abnormal lipid profile and 20% patients had normal lipid profile.

Keywords: type 2, diabetes mellitus, triglycerides, low density lipoprotein, high density lipoprotein.

1. Stamouli M, Pouliakis A, Mourtzikou A, Skliris A, Panagiotou I, Mournianakis E, Totos G. Evaluation of the lipid profile in type 2 diabetes mellitus patients in Greece.Clin Lab. 2014;60(10):1593-600. .
2. AclanOzderLipid profile abnormalities seen in T2DM patients in primary healthcare in Turkey: a cross-sectional studyLipids Health Dis. 2014; 13: 183.
3. Mooradian AD. Dyslipidemia in type 2 diabetes mellitus.Nat Clin Pract Endocrinol Metab. 2009 Mar;5(3):150-9.
4. He S, Wang S, Chen X, Jiang L, Peng Y, Li L, Wan L, Cui K.Higher ratio of triglyceride to high-density lipoprotein cholesterol may predispose to diabetes mellitus: 15-year prospective study in a general population. Metabolism. 2012 Jan;61(1):30-6.
5. Rafael Bitzur, MD, Hofit Cohen, MD, Yehuda Kamari, MD, Aviv Shaish, PHD, and DrorHarats, MDTriglycerides and HDL CholesterolDiabetes Care. 2009 Nov; 32(Suppl 2):S373–S377.
6. Bishwajit Bhowmik, Tasnima Siddiquee, Anindita Mujumder, Faria Afsana, Tareen Ahmed, Ibrahimu A. Mdala, Nayla Cristina do V. Moreira, AbulKalam Azad Khan, AkhtarHussain, Gerd Holmboe-Ottesen, and Tone Kristin Omsland Serum Lipid Profile and Its Association with Diabetes and Prediabetes in a Rural Bangladeshi PopulationInt J Environ Res Public Health. 2018 Sep; 15(9): 1944.
7. Choudhury KN, Mainuddin AK, Wahiduzzaman M, Islam SM. Serum lipid profile and its association with hypertension in Bangladesh.Vasc Health Risk Manag. 2014 Jun 30;10:327-32. doi: 10.2147/VHRM.S61019. eCollection 2014.
8. Krauss RM Lipids and lipoproteins in patients with type 2 diabetes.Diabetes Care. 2004 Jun;27(6):1496-504.
9. Rana JS, Liu JY, Moffet HH, Solomon MD, Go AS, Jaffe MG, Karter AJAm J Metabolic Dyslipidemia and Risk of Coronary Heart Disease in 28,318 Adults With Diabetes Mellitus and Low-Density Lipoprotein Cholesterol <100 mg/dl. Cardiol. 2015 Dec 1;116(11):1700-4
10. Siraj ES, Seyoum B, Saenz C, Abdulkadir J. Lipid and lipoprotein profiles in Ethiopian patients with diabetes mellitus. Metabolism. 2006 Jun;55(6):706-10.
11. Gadi R, Samaha FF. Dyslipidemia in type 2 diabetes mellitus.CurrDiab Rep. 2007 Jun;7(3):228-34
12. Santos-Gallego CG, Rosenson RS.Role of HDL in those with diabetes.CurrCardiol Rep. 2014 Aug;16(8):512.
13. He S, Wang S, Chen X, Jiang L, Peng Y, Li L, Wan L, Cui K. Higher ratio of triglyceride to high-density lipoprotein cholesterol may predispose to diabetes mellitus: 15-year prospective study in a general population. Metabolism. 2012 Jan; 61(1):30-6.
14. Giannini C, Santoro N, Caprio S, Kim G, Lartaud D, Shaw M, Pierpont B, Weiss R. The triglyceride-to-HDL cholesterol ratio: association with insulin resistance in obese youths of different ethnic backgrounds. Diabetes Care. 2011 Aug;34(8):1869-74.
15. Prashant Regmi , Prajwal Gyawali , Rojeet Shrestha , Manoj Sigdel , Kisun D Mehta , Shankar Majhi Pattern of Dyslipidemia in Type  Diabetic Subjects in Eastern Nepal .Journal of Nepal Association for Medical Laboratory Sciences P. 11-13
16. Lewis GF, Uffelman KD, Szeto LW, Weller B, Steiner G.Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans.JClin Invest. 1995 Jan; 95(1):158-66.
17. Ram VinodMahato, Prajwal Gyawali, Pramod Psd. Raut, Prashant Regmi, Khelanand Psd. Singh, Dipendra Raj Pandeya and Prabin Gyawali Association between glycaemic control and serum lipid profile in type 2 diabetic patients: Glycated haemoglobin as a dual biomarker Biomedical Research (2011) Volume 22, Issue 3
18. Diabetic dyslipidaemia: from basic research to clinical practice. Diabetologia. 2003 Jun;46(6):733-49. Epub 2003 May 28
19. Taskinen MR Diabetic dyslipidemia. Atheroscler Suppl. 2002 May;3(1):47-51.
20. Zhu XW, Deng FY, Lei SF Meta-analysis of Atherogenic Index of Plasma and other lipid parameters in relation to risk of type 2 diabetes mellitus.Prim Care Diabetes. 2015 Feb;9(1):60-7.
21. Zhu XW, Deng FY, Lei SF.Meta-analysis of Atherogenic Index of Plasma and other lipid parameters in relation to risk of type 2 diabetes mellitus.Prim Care Diabetes. 2015 Feb;9(1):60-7.
22. Elnasri HA, Ahmed AM. Patterns of lipid changes among type 2 diabetes patients in Sudan. East Mediterr Health J. 2008 Mar-Apr;14(2):314-24.
23. S. Kalsi, Jyoti Chopra, and Anchal Sood Association of lipid profile test values, type-2 diabetes mellitus, and periodontitis Indian J Dent. 2015 Apr-Jun; 6(2): 81–84.

Dr Dharmendra Kumar Mishra

Junior Resident, Department of Medicine (KPS Institute) GSVM Medical College Kanpur 208002, India