In this article, we present a case of a 27 year old male patient with symptoms and signs suggestive of vasculitis in fingers of upper as well as lower extremities. He was an old case of sputum positive pulmonary tuberculosis for which he received 6 months of antitubercular therapy with isonazide 300mg /day. Prompt diagnosis and treatment in cases of vasculitis is important to prevent irreversible damage to the limb as well as organs. This patient’s all vasculitis workup was negative except ANA homogeneous pattern and antihistone antibody positive  Reported here is a case of isoniazid-induced lupus  presenting with vasculitis. This patient was treated with steroids and cyclophosphamide. He responded well to therapy. The existing literature on the subject is reviewed.

Keywords: Isoniazide, Blood vessel, Drug induced lupus, vasculitis.

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Dr Swapnil Kanire

Department of Internal Medicine and Critical Care, Apple Saraswati Multispeciality Hospital and Research Institute Kolhapur, Maharashtra, India