Purpose: To compare the clinical profile and morphological pattern of Diabetic maculopathy using Optical Coherence Tomography (OCT) in Diabetes mellitus patients with and without Diabetic Nephropathy.

Design: Comparative cross sectional study.

Materials and Methods: 150 patients were enrolled, their clinical profile and diabetic retinopathy status were assessed. Quantitative analysis and morphological pattern of macular edema was compared between the patient having diabetic nephropathy and without nephropathy. Diabetic nephropathy was determined by patient having microalbuminuria, detected by doing spot urine albumin creatinine ratio.

Results: Out of 150 patients 66.7% patients with Diabetic Nephropathy and 33.3% without microalbuminuria. 50% had moderate NPDR, 22.7% with severe NPDR, 22.7% with PDR, 4.7% with mild NPDR changes. Statistical significant difference was seen in better visual acuity (6/6 to 6/18) in patient with (28%) and without diabetic nephropathy group (46%). No significant difference was observed in maculopathy status between two groups. Duration of diabetes and hypertension showed no significant difference with the maculopathy severity. OCT pattern in macular edema between two groups showed no significant differences. Mean central foveal thickness in diabetic nephropathy group was 312.62  85.915 and without diabetic nephropathy was 289  73.748, No significant difference was observed.

Conclusion: Patient without diabetic nephropathy had good vision. Early stage of diabetic nephropathy in the form of microalbuminuria showed no increase in the central foveal thickness. Diabetic nephropathy did not influence the morphological pattern of macular edema.

Keywords: Clinical profile; OCT pattern; Diabetic Maculopathy; Diabetic Nephropathy.

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Nethaji Sellaram S

Department of Ophthalmology, Govt. TD Medical College, Alappuzha, Kerala – 688005, India