Introduction: Vesiculobullous eruptions are encountered in various dermatosis, which include various inflammatory, infective, autoimmune, drug induced as well as genetic. Primary lesion in vesiculobullous diseases is a vesicle or a bulla involving skin and/or mucous membrane.

Aim: To study the histomorphological features of various vesiculobullous disorders of skin with clinical correlation.

Materials and Methods: A laboratory based cross-sectional observational study was conducted over a period of 10 months from June 2018 to March 2019 in the Department of Pathology, S.M.S Medical College, Jaipur. 55 clinically diagnosed cases of vesiculobullous lesions of the skin included in the study.

Results: Out of 55 cases of vesiculobullous disorders Pemphigus vulgaris constituted the most common disease with 49.09% followed by Bullous pemphigoid 12.72%. Out of the 55 cases, 50 cases were clinically diagnosed as one of the varieties of vesiculobullous lesions, which were confirmed on histology.

Conclusion: Pemphigus vulgaris constituted the most common subtype of vesiculobullous disorder in this study followed by Bullous pemphigoid. Clinicopathological correlation is very important in the diagnosis of vesiculobullous disorders rather than considering either of them alone.

Keywords: Vesiculobullous disorders, Pemphigus vulgaris, Bullous pemphigoid.

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Yadav Ajay

Senior Professor, Department of Pathology, SMS Medical College, Jaipur, Rajasthan, India