Background and Aims: This study aimed at the comparative study of etomidate versus propofol as induction agent on haemodynamic parameters during endotracheal intubation using entropy guided hypnosis levels in general anaesthesia.

Material and Methods: 60 patients in the age group 18-50 years with ASA I & II, undergoing endotracheal intubation during general anaesthesia were randomly distributed in 2 groups based on induction agent Etomidate/Propofol. Tab. Alprazolam (0.25 mg) & Ranitidine (150mg) on the night before surgery. Ranitidine (50mg i.v), inj. Glycopyrrolate (0.25mg i.v) and inj. Metoclopramide (10mg i.v), are given as premedication. After induction with desired agent titrated to entropy 40, vecuronium 0.1 mg/kg was administered for neuromuscular blockade. HR, SBP, DBP and MAP, response entropy [RE] and state entropy [SE] were recorded at baseline, induction and upto 3 mins post intubation. Data was subject to statistical analysis SPSS the paired and the unpaired Student’s T-tests for equality of means.

Results: Etomidate provided more hemodynamic stability without the requirement of any rescue drugs whereas rescue drug mephentermine was required in patients with propofol group.

Conclusion: Etomidate is more hemodynamically stable than propofol during induction and intubation during general anaesthesia. Reduced induction doses of etomidate and propofol titrated to entropy translated into increased hemodynamic stability for both drugs and sufficed to give an adequate anaesthetic depth.

Keywords: Entropy, etomidate, hemodynamic changes, propofol.

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Dr Mukesh Kumar

Associate Professor, Department of Anaesthesiology, Rajendra institute of Medical sciences, Ranchi, India