Background: It is recognized that inflammatory markers high sentive c-reactive protein, thyroid profile, and uric acid were collectively called as non-lipid risk factors also as added risks of metabolic syndrome (MS). There were sex-specific associations among various risk parameters in MS. A standardized incidence of MS in total was 24.2%, in that, 24.6% men and 23.8% women. A study existed the prevalence of SMS was 21.9% in adults aged 50 years, and in adolescents, it remains 8.0%. Also, women presented a higher incidence of SMS when compared to men aged <50 years, 76.3% women, and 20.7% men ≥50 years, 86.2% women, and 13.8% men.

Methods: A total of 450 participants (211 men and 239 women) aged ≥35 years divided into three groups (150 participants in each group), according to the number of parameters of MS risk factors. Group I: Subjects with less than any of the three components of MS (Control group), Group II: Subjects with any three variables of MS(MS group), Group III: Subjects with more than three components of MS(Severe MS group {SMS}). The data were analyzed by one-way ANOVA and with Student-Newman-Keul’s multiple comparison method.

Results: The value of non-lipid risk parameters hs-CRP in MS, and SMS groups in male found a high significance than Control (P<0.001), but not significant (P = 0.156) in the female. The value of UA found high significance value (P = 0.001) in male and highly significant than Control (P<0.001) in MS, and SMS in the female. The T₃ of the Control group was, compared with MS, SMS groups, and not significant (P = 0.185) in males, was significant (P=0.039)in the female. In the case of thyroxin (T₄), values were significantly high in males and females (P = 0.002 and P<0.001), respectively. TSH (µIU/mL) Control group was significantly high (P = 0.009) in male MS and SMS groups, but not significant (P = 0.913) in female.

Conclusion: The comparison of specific non-lipid risk parameters like high-sensitivity C-reactive protein, uric acid, triiodothyronine, thyroxin, and TSH in MS and SMS in males and females that significantly differed in MS and SMS than the normal.

Keywords: Metabolic syndrome; Non-lipid risks; hs-CRP; Uric acid; TSH.

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Srinivasa Babu V

Assistant Professor, Department of Physiology, Nimra Institute of Medical Sciences and Research Foundation, Ibrahimpatnam, Vijayawada, Andhra Pradesh - 521456, INDIA