Introduction: Nephrectomy is a surgical procedure done for various conditions like chronic pyelonephritis, calculi, malignancies, obstruction and injury etc. Histopathological spectrum of various lesions in nephrectomy spectrum were studied to assess the patterns and morphology of lesions and to observe variation if any from the conventional pattern.

Materials & Method: The study was conducted in the Department of Pathology GMC Jammu over a period of 3 years from Dec 2016 to Jan 2020. 55 nephrectomy specimens were received from the surgical Department of the Hospital.

Results: Out of 55 nephrectomy specimens. 44 (80%) were benign and 11(20%) were malignant. Age ranged from 1 year to 72 years with the maximum cases seen in 51-60 years of age. Maximum cases were of Chronic Pyelonephritis 29 (52.72%), some associated with calculi and others with hydronephrosis. Renal Cell Carcinoma constituted 6 cases (10.90%) out of 11 total malignant lesions. Wilm’s tumour was the commonest malignant tumour seen in children. Most common clinical presentation was flank pain followed by burning micturition and fever.

Conclusion: Benign lesions outnumber the malignant. Chronic Pyelonephritis was the most common histopathological diagnosis and Renal Cell Carcinoma was commonest among the malignant lesions.

Keywords: Nephrectomy, Chronic Pyelonephritis (CPN), Kidney, Histopathology, Renal Cell Carcinoma (RCC).

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Dr Anu Gupta

Lecturer, Department of Pathology, Govt. Medical College, Jammu