Background: Ovarian tumors account for 30% of all cancers of female genital tract which represents the seventh most common cause of cancer and fourth leading cause of death in women. The present study was done with an objective to analyze the frequency of histopathological spectrum of ovarian tumors in our department.

Method: The present two year retrospective study was carried out in the department of Pathology, Government Medical College, Trivandrum from January 2015 to December 2016.

Results: In this study a total of 597 histopathologically proven ovarian tumors were included. These were removed from 570 patients. 27 of them had bilateral ovarian tumors. Majority of ovarian tumors were seen in the age group of 40-49 years (24%) and least below 10 years (0.3%). The most common ovarian tumor encountered was surface epithelial tumor (79%), followed by germ cell tumors (25.5%), sex cord stromal tumors (4.2%), metastasis (0.34%). Serous cystadenoma was the most common surface epithelial tumor (36.7%) and among germ cell tumors, benign cystic teratoma was commonest (24.12%), adult granulosa cell tumors among sex cord stromal tumors (1.51%). In the present study, 85% cases were benign tumors , 3.34% were borderline tumors and 11. 6% were malignant tumors. Commonest clinical presentation for both benign and malignant tumors was abdominal pain followed by mass abdomen.

Conclusion: The majority of ovarian tumors in our study were benign and unilateral. Most common age group with ovarian tumors was 40-49 years .

Keywords: Benign, malignant surface epithelial tumors, Histopathology

1. Basu P, De P, Mandal S, Ray K, Biswas J. Study of'patterns of care'of ovarian cancer patients in a specialized cancer institute in Kolkata, eastern India. Indian journal of cancer. 2009 Jan 1;46(1):28.-33 Cross ref
2. Young R.H. The ovary. In : Sternberg’s diagnostic surgical pathology 17^th New York Raven Press;1994 p2195
3. Sikdar K, Kumar P, Roychowdhary NN. A study of ovarian malignancy: A review of 149 cases. J ObstetGynaecol India. 1981 ;30:478-80  
4. Rosai . J. Female reproductive system: Ackerman’s surgical pathology, 8^th Mosby – year book Inc . Newyork; 1996 p1473 – 539.
5. Modan B, Hartge P, Hirsh-Yechezkel G, Chetrit A, Lubin F, Beller U, Ben-Baruch G, Fishman A, Menczer J, Struewing JP, Tucker MA. Parity, oral contraceptives, and the risk of ovarian cancer among carriers and noncarriers of a BRCA1 or BRCA2 mutation. New England Journal of Medicine. 2001 Jul 26;345(4):235-40.
6. Clement PB., Young RH. Ovarian Surface Epithelial — Stromal Tumors. In: Mills SE, editor. Sternberg’s Diagnostic Surgical Pathology. 5 th ed. Philadelphia: Lippincott Williams and Wilkins, 2004. 2278–2308
7. Tavassoli FA, Deville P, World Health Organization classification of tumors. Pathology and genetics of the tumors of breast and female genital organs. Lyon: IARC press; 2003. p. 113-96
8. Gupta N, Bisht D, Agarwal AK, Sharma VK. Retrospective and prospective study of ovarian tumours and tumour-like lesions. Indian journal of pathology & microbiology. 2007 Jul;50(3):525-7.
9. Jha R, Karki S. Histological pattern of ovarian tumors and their age distribution. Nepal Med Coll J. 2008 Jun;10(2):81-5.
10. Kuladeepa AV, Muddegowda PH, Lingegowda JB, Doddikoppad MM, Basavaraja PK, Hiremath SS. Histomorphological study of 134 primary ovarian tumours. Adv Lab Med Int. 2011;1(4):69-82.
11. Sohail I, Hayat Z, Saeed S. A comparative analysis of frequency and patterns of ovarian tumours at a tertiary care hospital between two different study periods (2002-2009). Journal of Postgraduate Medical Institute (Peshawar-Pakistan). 2012 Mar 23;26(2).
12. Prabhakar BR, Maingi K. Ovarian tumours--prevalence in Punjab. Indian journal of pathology & microbiology. 1989 Oct;32(4):276-81.
13. Mishra RK, Sharma SP, Gupta U, et al. Pattern of ovarian neoplasm in eastern UP. J ObstetGynaecol India 1991;30:242-6.
14. Couto F, Nadkarni NS, Jose M. Ovarian tumours in Goa: A clinicopathological study. J ObstetGynecol India. 1993;40(2):408-11.
15. Kar, T., Kar, A. and Mohapatra, P.C. Intra-Operative Cytology of Ovarian Tumors. The Journal of Obstetrics and Gynecology of India, 2005), 55, 345-349.
16. Swamy GG, Satyanarayana N. Clinicopathological analysis of ovarian tumours: a study on five years samples. Nepal Med Coll J. 2010 Dec;12(4):221-3.
17. Pilli GS, Suneeta KP, Dhaded AV, Yenni VV. Ovarian tumours: a study of 282 cases. Journal of the Indian Medical Association. 2002 Jul;100(7):420-3.
18. Yasmin S, Yasmin A, Asif M. Clinicohistological pattern of ovarian tumours in Peshawar region. J Ayub Med Coll Abbottabad. 2008 Dec 1;20(4):11-3.
19. Sharadha SO, Sridevi TA, Renukadevi TK, Gowri R, Binayak D, Indra V. Ovarian masses: changing clinico histopathological trends. The Journal of Obstetrics and Gynecology of India. 2015 Feb 1;65(1):34-8.
20. American College of Obstetricians and Gynecologists. Salpingectomy for ovarian cancer prevention. Committee opinion no. 620. Obstet Gynecol. 2015;125:279-81.

Dr Sheela K. M

Associate Professor (Non cadre), Government Medical College, Thiruvananthapuram, India