Introduction: Diabetes mellitus is a chronic and a progressive disease. The risk of at herothrombotic complication is increased in diabetics. Research has shown a diverse of Diabetes mellitus related abnormalities especially in haemostasis and thrombosis. The main objective of this study was to investigate the Prothrombin time and Activated partial thromboplastin time in Diabetes mellitus patients.

Methodology: Descriptive analytical cross-sectional study was employed to recruit 371 participants. Venous blood was collected (4.5 mls) in 3.2% trisodium citrate (0.5 mls) for prothrombin time and activated partial thromboplastin time testing. It was analyzed using coagulation analyzer (Start 4). Capillary blood was used for glucose estimation by glucose oxidase method.

Results: There was low degree of correlation between prothrombin time, international normalized ratio and activated partial thromboplastin  time of diabetics as compared to the controls (R=4%, p=0.215, R=4%, P=0.221 and R=4%, P=0.445 respectively). There was statistical significant in activated partial thromboplastin time in relation to age (p=0.005) with no statistical significant in prothrombin time (0.839) and international normalized ratio (p=0.880).

Conclusion: Prothrombin time and international normalized ratio were not significantly affected by the diabetic state of the study subjects. Activated partial thromboplastin time had a significant difference in age group means revealing hypercoagulable state. Preventive measures should be undertaken in these age groups to ensure complications associated with hypercoagulable state do not occur.                                                                                       

Keywords: Prothrombin time, Activated partial thromboplastin time, International normalized ratio, hypercoagulable.

1. Awad A, Hassan A, Babiker L. Assessment of some coagulation parameters ( PT , APTT , INR , PLTS COUNT and PLT indices ) in Sudanese Patients with Diabetic Type 2 January 2016. 2016;IV(2):1570-1585.
2. Singh R. Original Article. 2013;15(03):77-82.
3. Dallatu MK. Evaluation of Prothrombin Time and Activated Partial Thromboplastin in Patients with Diabetes Mellitus. 2012;20(1):60-63.
4. Shah VN, Mohan V. Diabetes in India: What is different? Curr Opin Endocrinol Diabetes Obes.2015;22(4):283-289. doi:10.1097/MED.0000000000000166
5. Banoo H, Nusrat N NN. Type2 diabetes mellitus: a review of current trends.Rama Univ J Med Sci. 2015;1(2):50-57.
6. Pahim H, Megalamane S. Platelet Indices and Basic Coagulation Profile of Type 2 Diabetic Patients undergoing Haemodialysis in Rural Population. J Clin Diagnostic Res. 2017;11(10):9-12. doi:10.7860/JCDR/2017/30241.10713
7. Erem C, Hacıhasanoğlu A, Çelik Ş, et al. Coagulation and Fibrinolysis Parameters in Type 2 Diabetic Patients with and without Diabetic Vascular Complications. Med Princ Pract. 2004;14(1):22-30. doi:10.1159/000081919
8. Onbafl K. Diabetes Mellitus and the Natural Anticoagulants. 1999:53-63.
9. Mwambungu A. Risk Factors Associated with Hypercoagulability in Type 2 Diabetes Mellitus Patients at Ndola Central Hospital Zambia.Med J Zambia, . 2014;41(2):70-80.
10. Ephraim RKD, Awuku YA, Adu P, et al. High risk of coagulopathy among Type-2 Diabetes Mellitus clients at a municipal hospital in Ghana. 2017;51(3):101-107.
11. Agarwal C, Bansal K, Pujani M, et al. Hematology , Transfusion and Cell Therapy Original article Association of coagulation profile with microvascular complications and glycemic control in type 2 diabetes mellitus – a study at a tertiary care center in Delhi. Hematol Transfus Cell Ther. 2018;41(1):31-36. doi:10.1016/j.htct.2018.05.002
12. Chaitanya PK, Kavuri S. International Journal of Pharma and Bio Sciences issn comparison of prothrombin time and activated partial thromboplastin time between patients with diabetes mellitus and diabetics with hypertension. 2014;5(3):705-709.
13. Ogedegbe HO, Sc BBA. An Overview of Hemostasis. 2002;33(12).
14. Madan R, Gupta B, Saluja S, Kansra UC, Tripathi BK, Guliani BP. Coagulation profile in diabetes and its association with diabetic microvascular complications. J Assoc Physicians India. 2010;58(8):481-484.
15. Dhule S, Gawali S. Platelet aggregation and clotting time in type 2 diabetic males. Natl J Physiol Pharm Pharmacol. 2014;4(2):121. doi:10.5455/njppp.2014.4.290920131.

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