Title: Correlation of Novel Risk Factors with Syntax Score in Young and Elderly Males with Coronary Artery Disease
Authors: Ushnish Chakrabarty, Swarnendu Datta, Plaban Mukherjee
DOI: https://dx.doi.org/10.18535/jmscr/v8i1.59
Abstract
Worldwide, Coronary Artery Disease (CAD) is one of the leading causes of death. Patients from the Indian subcontinent present relatively early and may have more extensive CAD. Various Conventional and Novel risk factors for CAD have been studied. In this study apart from the Conventional risk factors, we assessed the Novel risk factors like Hyperhomocysteinaemia, Lipoprotein a (Lpa), Apolipoprotein B (Apo B), Apolipoprotein A1 (Apo A1) and Apolipoprotein B/A ratio in both the Elderly (>45 years) & Young (≤45years) groups and correlated their values with the SYNTAX Score to find out if there was any correlation between the levels of the Novel risk factors and the SYNTAX score. We found that the Homocysteine levels in young patients correlated linearly with their respective Syntax scores with a highly significant ‘p’ value of 0.001355. This was however not so in the elderly group. It was also derived from this study that serum Homocysteine levels in young coronary artery disease patients are 83.33% sensitive, 91.67% specific and 86.67% accurate in predicting complexity of coronary lesions and thus the aggressiveness of the disease in terms of their Syntax scores.
References
- Vardan S, Mookherjee S, Vardan S, Sinha AK. Special Features of coronary heart disease in people of the Indian sub-continent. Indian Heart J 1995;47:399-407.
- Klein LW, Agarwal JB, Herlich MB. Prognosis of symptomatic coronary artery disease in young adults aged 40 years or less. Am J Cardiol 1987; 60:1267-72.
- The Asia Pacific perspective. Redefining obesity and its treatment. World Health Organization. International association for the study of obesity and International obesity task force. International Diabetes Institute, Melbourne: World Health Organization, Western Pacific Region; 2000.
- Boushey CJ, Bareford SAA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intake. J Am Med Asso 1995;274:1049-57.