Title: Serum Ferritin: A Biomarker to predict Disease Severity in Patients with Dengue Infection
Authors: Dr S A Kanitkar, Dr Murukoti Sonika Reddy, Dr Anu Gaikwad, Dr Vaja Mukhtarahmed, Dr Sura Sreekar, Dr Priyanka Reddy Produturu, Dr Mankoskar Yash Surendrakumar
DOI: https://dx.doi.org/10.18535/jmscr/v8i1.16
Abstract
Background: Each year, up to 400 million people are infected and 22,000 die from severe dengue globally. An important cause of acute febrile illness especially in tropics and subtropics in the world is dengue fever. It is approximated that one million dengue cases are reported to WHO from these regions. Aim of the study was early detection of dengue severity using ferritin as a biomarker in dengue patients.
Methods: A retrospective study was conducted on 50 patients in Department of Medicine from November 2018 to December 2019. Data of all patients admitted with dengue were collected and analysed with special reference to serum ferritin.
Results: In 50 patients, majority were in the age group of 20-40 years. Mean ferritin level was much higher in severe dengue patients i.e. 861.28 ± 183.17 as compared to patients with non severe dengue i.e. 400 ± 151.7. Serum ferritin levels was high in patients with severe dengue as compared to non severe forms.
Conclusion: Serum ferritin levels may serve as a biomarker to predict dengue disease severity
Keywords: severe dengue, serum ferritin, dengue fever.
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