Creutzfeldt-Jakob disease (CJD) is a rare fatal rapidly progressive dementing disorder. The estimated annual incidence was 0.5 to 1.5 million populations. The illness is relentlessly progressive and generally causes death within 9 months of onset. Most CJD patients presents between 60 and 75 years of age.

Here by we report a case of sporadic Creutzfeldt-Jakob disease presenting as rapidly progressive neurodegenerative disorder.

Keywords: Creutzfeldt-Jakob, Prion, Delta activity.

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Taraka Ravi Kiran Komanapalli