Title: Peripapillary Retinal Nerve Fiber Layer Thickness in Patients with Chronic Migraine
Authors: Dr Debabrata Das, MS (Ophthal)1, Dr Somedeb Gupta,MS (Ophthal)
DOI: https://dx.doi.org/10.18535/jmscr/v7i12.110
Abstract
Purpose: To evaluate thickness of the peripapillary retinal nerve fiber layer (RNFL) by optical coherence tomography (OCT) among subjects with migraine headache and to compare it with healthy subjects.
Materials and Methods: This is a prospective cross-sectional study of 65 subjects with chronic migraine headache, aged between 18 and 40 years and 65 healthy subjects of same age group without headache as control group., Intraocular pressure (IOP) and axial length (AL) were measured in each case of both the study groups. Peripapillary RNFL was measured using OCT in all participants and then it was compared between migraine and control group.
Results: In this study, mean age of the participants was 31.84±6.03 years in migraine headache group and 31.69±5.94 years in control group. The mean duration of migraine in patients after diagnosis was 7.84±6.03 years. The average peripapillary RNFL thickness was 95.84±6.03 µm in migraine headache group and 97.32±7.08 µm in control group. The mean superior quadrant RNFL thickness was 115.84±13.03 µm in migraine headache group, 121.85±14.72 µm in control group. The average peripapillary RNFL thickness and the superior quadrant thickness was statistically significant different between migraine and control groups (p =0.0031,p =0.0150 respectively).The measurements of the RNFL thickness in inferior, temporal and nasal quadrant were not statistically significant between migraine and control groups.
Conclusion: The average and superior quadrant peripapillary RNFL were thinner in patients with chronic migraine than the healthy participants.
Keywords: Migraine, Optical Coherence Tomography, Peripapillary RNFL.
References
- Otesen J, Bes A, Kunket. The International classification of headache disorders. 3rd ed. Headache Classification Subcommitte of the International Headache Society: Blabkweit Publishing. Cephalalgia 2013;33: 629-808.
- Roy MK, Ghosh P. Prevention of Migraine .Medicine Update 2008;18;379-382
- Shivpuri D, Rajesh MS, Jain D. Prevalence and characteristics of migraine among adolescents: a questionnaire survey. Indian Pediatr 2003;40:665-9
- Gorayeb MA, Gorayeb R. Association between headache and anxiety disorders indicators in a school sample from Ribeirao Petro ,Brazil .Arq Neuropsiquiatr 2002;60:764-8
- Kulkarni G, Rao G, Gururaj G, Subbakrishna DK, Steiner T, Stovner IJ. The prevalence and burden of migraine in India: results of a population –based study in Karnataka state. The Journal of Headache and Pain 2014;15:818
- Padhye AS, Khandekar R, Dharmadhikari S, Dole K,Gogate P, Deshpande M. Prevalence of uncorrected refractive error and other eye problems among urban and rural school children. Middle East African Journal of Ophthalmology 2009;16:69-74
- Haq I, Khan Z, Khalique N, Jilani FA, Zaidi M, Prevalence of common ocular morbidities in adult population of Aligarh. Indian J Community Med 2009;34:196-201
- Martinez A, Proupim N, Sanchez M. Retinal nerve fibre layer thickness measurements using optical coherence tomography in migraine patients.Br J Ophthalmol 2008;92:1069-75
- Killer HE, Forrer A, Flammer J. Retinal vasospasm during an attack of migraine. Retina 2003;23:253-4
- Gipponi S, Scaroni N, Venturelli E, Forbice E, Rao R, Liberini P, et al. Reduction in retinalnerve fiber layer thickness in migraine patients. Neurol Sci. 2013;34:841-5.
- Shin HJ, Cho BJ. Comparison of retinal nerve fiber layer thickness between Stratus and Spectralis OCT. Korean J Ophthalmol. 2011;25:166-73.
- Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W. Optical coherence tomography. Science 1991; 254:1178-81.
- Schuman JS, Pedut-Kloizman T, Hertzmark E, Hee MR, Wilkins JR, Coker JG. Reproducibility of nerve fiber layer thickness measurements using optical coherence tomography. Ophthalmology 1996;103:1889-98.
- Blumenthal EZ, Williams JM, Weinreb RN, Girkin CA, Berry CC, Zangwill LM. Reproducibility of nerve fiber layer thickness measurements by use of optical coherence tomography. Ophthalmology 2000;107:2278-82.
- Kirbas S, Turkyilmaz K, Anlar O, Tufekci A, Durmus M. Retinal nerve fiber layer thickness in Alzheimer disease. J Neuroophthalmol. 2013;33(1):58-61.
- Colak HN, Kantar FA. Retinal nerve fiber layer, ganglion cell complex, and choroidal thickness in migraine. Arq Bras Oftalmol 2016;79:78-81.
- Sorkhabi R, Mostafaei S, Ahoor M, Talebi M. Evaluation of retinal nerve fber layer thickness in migrane. Ir J of Neurol 2013;12:51-55.