Objective & Aim: In gastrointestinal (GI) endoscopy, Propofol has revolutionised sedation practices as it can be easily titrated and has a rapid recovery profile. This observational real-world study was initiated specially in patients who were undergoing GI endoscopy sedation to compare efficacy and safety of propofol with midazolam and fentanyl combination.

Methods: 80 patients who are admired at Katihar medical College and hospital and scheduled for gastrointestinal endoscopy process were recruited for this real word observational study. Patients was divided in two groups which contains either Group A (propofol alone) or Group B (combination of midazolam plus fentanyl). Efficacy was measured by the parameters like depth of sedation (Ramsays sedation scale), time of onset of sedation, amnesia and early recovery of sedation (Modified Aldrete Score). Cardiovascular and respiratory parameters were used to evaluate safety parameters. Adverse events like hypotension, hypoxia and bradycardia were recorded. For statistical analysis, PSPP software was used.

Result: With a mean RSS of 4.9, A group patients were more deeply sedated compared to 3.2 of the B group. At ten minutes after the end of the procedure, full recovery (Aldrete score 10) was seen in 73.33% of the patients of the A group compared to 50% of the B group which was insignificant. Significant haemodynamic changes (hypotension) had observed in A group as compared to B group. Few statistically non-significant respiratory complications were seen in both the groups.

Conclusion: Both the groups present with almost same efficacy and safe.

Keywords: Propofol, Midazolam plus Fentanyl Combination, GI endoscopy sedation.

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Dr Rakesh Ranjan Singh

Associate Professor, Department of Anaesthesia, Katihar Medical College & Hospital, Karimbagh, Katihar, Bihar