Title: Diagnostic Utility of Bone Marrow Aspiration and Bone Marrow Biopsy in Hematological Practice
Authors: Dr Neema Ankur Rana, Dr Neelam Shah, Dr Meena Daveshvar, Dr Hiral Shah, Dr Hemali Tailor, Dr Smita C. Patel
DOI: https://dx.doi.org/10.18535/jmscr/v7i12.29
Abstract
Introduction: Bone marrow aspiration (BMA) and bone marrow biopsy (BMB) are important diagnostic procedures. We have found that when both the procedures are performed simultaneously they are complementary to each other. The study was conducted to determine and compare the diagnostic efficiency of bone marrow aspiration and trephine biopsy done simultaneously.
Material and Methods: A total no of 100 cases, where both BMA and BMB were done simultaneously on admitted patients, have been reviewed. The results have been compared with that of previously published literature.
Results: We have found that 76.0% cases showed positive correlation between bone marrow aspiration and biopsy findings. Out of 100 cases, bone marrow aspiration was diagnostic in 86.0% of cases while bone marrow biopsy was diagnostic in 87.0% of cases. Nutritional anemia, hematological malignancies and immune thrombocytopenic purpura can be easily diagnosed by bone marrow aspiration alone while bone marrow trephine biopsy is standard for diagnosis of granulomatous inflammation and hypoplastic /Aplastic anemia.
Conclusion: Our study suggests that bone marrow aspiration is easy to perform and important for morphological assessment. Bone marrow trephine biopsy is more reliable in assessing cellularity, bone marrow architectural pattern, distribution of cell and fibrosis. Overall both the procedures are complementary to each other and must be performed together for better evaluation of bone marrow.
Keywords: BMA-Bone marrow aspiration, BMB-Bone marrow biopsy.
References
- Manjit Kaur, Amrit Pal Singh Rana, Shivali Kapoor ,Arun Puri- Diagnostic Value of Bone marrow Aspiration and Biopsy in routine Hematology Practice, Journal of Clinical and Diagnostic Reasearch, 2014 Aug , Vol-8(8):FC13-FC16.
- Chandra S, Chandra H. -Comparision of bone marrow aspirates cytology, touch imprints cytology and trephine biopsy for bone marrow evaluation. Hematol Rep 2011;3 e22
- Pampa Ch Toi, Renu G’Boy Varghese, Ramji Rai- Comparative Evaluation of simultaneous Bone marrow Aspiration and Bone marrow biopsy :An Institutional Experience, Indian Journal Of Hematology Blood Transfuse2010 Jun 26(2):41-44
- Riley RS, Hogan TF, Pavot DR, Forysthe R, Massey D ,Smith E, Wright L Jr, Ben-Ezra JM-A Pathologist’s perspective on bone marrow aspiration and biopsy ,performing bone marrow examination. Clin Lab Anal 2004:18(2):70
- Nirnjan Mainali, Neha Homagai, Pratap Sagar Tiwari, Arun Giri-A comparative study of bone marrow aspiration and bone marrow biopsy in hematological diseases ,Journal of Nobel Medical CollegeVol.4,No1 Issue
- Majdi H.A, Sanna D.S ,Nazmi Kamal, Mohammad B.O, Ayman S.A, Ali M.S, Ahmad Telfah-Comparative Evaluation between Bone marrow Aspirate and Biopsy Morpholgic Findings, Experince at King Hussein Medical Center, Journal of Royal Medical services, Vol 22 No2 June 2015.
- Taj Ali Khan, Irfan Ali Khan, Khalid Mahmood, J Postgrad Med Inst 2014 vol. 28 No 2,217-21, Diagnostic Role of Bone Marrow Aspiration And Trephine Biopsy In Hematological Practice
- Steven J.Jubelier and Robert Harpold-The Role of the bone marrow examination in the diagnosis of Immune Thrombocytopenic Purpura:case series and and literature review.
- Manju,Vanita Kumar, Neetu Gupta, Akhil Kapoor, Harvindra Singh Kumar-Role of Bone marrow Biopsy in Diagnosis of Hematological Disorders: A prospective Study Journal Pharm Biomed Sci/Vol.06 No.03/150-154
- Surbhi Goyal,Usha Rani Singh and Usha Rusia-Mediterranean Journal of Hematology and Infectious Diseases 2014;6.
- Sabharwal BD ,Malhotra V, Aruna S, Grewal R-Comparative evaluation of bone marrow particle smears, imprints and biopsy section. J Postgrad Med 1990;194-8.
- Amrish Pandya ,Tejas Patel, Neelam Shah-Comparative Utility of bone marrow and aspiration and bone marrow biopsy ,Journal of Evolution of Medical and Dental Science /volume 1 / Issue 6/December-2012.
- J Bain, Bone marrow aspiration, Journal of Clinical Pathology, Volume 54,Issue 9
- J Bain, Bone marrow trephine biopsy. Journal of Clinical Pathology,
- Tummidi et al-microfilaria in a bone marrow aspirate, BMC Res notes(2016) 9-256.