Title: Loading Dose Only Vs Standard 24 Hrs Pritchard’s Regimen of Magnesium Sulphate in Severe Pre-Eclampsia - A Randomised Trial
Authors: Dr Prachi, Dr Soma Bandyopadhyay, Dr Rashmi Sinha
DOI: https://dx.doi.org/10.18535/jmscr/v7i11.60
Abstract
Introduction
Hypertensive disorders of pregnancy affect about 10% of all pregnant women around the world. The pre-eclampsia affects 2-8% of all pregnancies worldwide. The primary aim of treatment in severe pre-eclampsia is to prevent eclamptic seizures & resultant morbidity & mortality. Magnesium sulphate is drug of choice for prevention of seizures in pre-eclampsia as well as treatment of seizures in eclampsia.
PRITCHARD REGIME recommends giving 4gms Inj MgSO4 IV over 5 minutes followed immediately by 10 gms IM and 5 gms IM every 4 hours. It has recently been suggested that an initial dose of inj MgSO4 is sufficient to arrest convulsion. We also observed that most of the patient did not receive maintenance therapy due to suspicion of toxicity & they did not convulse further. On the basis of these observations, a study was done to compare the efficacy of loading only & standard regime.
Aims and Objective
To determine the efficacy & safety of only loading dose of Pritchard regimen of MgSO4 therapy in patients of severe pre-eclampsia.
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