Title: Pregnancy in Sickle Cell Disease is a Very High-Risk Situation: A Case Control Study
Authors: Dr Akanksha Girish Mahajan MD (OBGY), CIMP, Dr Trupti Nagaria MD (OBGY), Dr Ruchi Kishore, MD (OBGY), Dr Chetan Pathak, DMRD, DNB
DOI: https://dx.doi.org/10.18535/jmscr/v7i11.32
Abstract
Background: A prospective, observational case control study to compare outcome of pregnancy in women with sickle cell disease (SCD) to normal haemoglobin.
Methods: All pregnant women with sickle cell disease who attended department of obstetrics and gynecology, Pt JNM medical college, Raipur were included in study. Age matched controls were included who had normal haemoglobin, in ratio 1:2. A detailed history was taken. All women were thoroughly examined and were properly followed and managed for any developing complications. Mothers were regularly screened for any developing medical/ obstetric complications throughout pregnancy, during delivery and in postpartum period till the discharge. The fetomaternal outcomes were compared using P value and paired T test whichever was suitable.
Results: Significant number of patients with SCD developed crisis, leg ulcers, AVN hip. Incidence of UTI, pneumonia, anemia, IUGR, severe oligohydramnios, preterm labor, post delivery wound infection were statistically significantly higher among cases as compared to controls. Requirement of blood transfusion, need of ventilatory support, duration of hospital stay, requirement of nursery admission for newborn was higher in cases as compared to controls.
Conclusion: Early booking, meticulous antenatal care and supervised hospital delivery will improve the maternal and fetal outcomes in the pregnant women with sickle cell disease.
Keywords: sickle cell disease, fetomaternal outcome, crisis, blood transfusion, Hb electrophoresis.
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