Title: Predictive Value of Radiation Induced Apoptosis in Response to Radiotherapy in Cancer Cervix Patients Attending Department of Radio Therapy, Govt. Medical College Thrissur, A Prospective Study
Authors: Dr Ajithkumar V R, Dr R Mahadevan, Dr Seena K B, Dr Jayakumar K L, Dr Jewel Joseph, Dr Prema K R, Dr Shehna A Khader
DOI: https://dx.doi.org/10.18535/jmscr/v7i11.15
Abstract
Aim: To correlate the apoptotic index with respect to radiation therapy in patients with carcinoma cervix attending Govt. Medical college, Thrissur.
Materials and Methods: Patients both early stage and locally advanced cervical cancer has been included in the study. Between December 2013 and September 2014. 26 patients were included in the study. Pre and post Radiotherapy biopsy of patients were taken and they were examined for Nuclear Pleomorphism, Hyper chromasia, Apotosis, Mitosis, Keratinisation, and Necrosis.
IHC was done using Bcl 2, Bax, and Ki - 67.
Results: Apoptotic index and markers favouring apoptosis can positively predict disease outcome. Patients with good apoptosis faired well in the study. But this has to be analysed in large cohort studies.
Bax is a predictive marker for apoptosis.
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