Title: Clinicoepidemiological Profile of Pemphigus
Authors: Dr Sheena Ann Simon, Dr Suja V
DOI: https://dx.doi.org/10.18535/jmscr/v7i10.126
Abstract
Introduction: Pemphigus refers to a group of acquired, chronic autoimmune blistering disorders presenting clinically by flaccid intraepidermal blisters, erosions and ulcerations on skin and mucosa. The study was aimed at evaluating the epidemiological and clinical features of pemphigus.
Methods: After taking history of clinically diagnosed pemphigus cases, characteristics of the lesions were noted. Extent of involvement of both skin and mucosa was graded using appropriate methods. Data was analysed using statistical package for social science version 10.
Results: Among the 30 patients, onset of the disease was noted in the younger age group in 16.7 %. In majority of the patients, duration of the disease was less than 6 months. Onset of the disease on mucosa alone was seen in 50 % cases and only 3.3% had mucocutaneous onset. Pain or burning sensation was present in 60% cases and pruritus in 40%. Based on body surface area, 53.3% had moderate degree and 26.7% had severe degree of skin involvement. Nikolsky’s sign was positive in only 75 % patients. Two pemphigus foliaceus cases had oral lesions and 1 had nasal lesions. Grade 1 oral mucosal involvement was found in 40.2% cases and 16.7% had grade 3 involvement. Two pemphigus vulgaris patients had paronychia and oral candidiasis was present in 12 patients.
Conclusion: Severe mucocutaneous pemphigus and onset in the younger age group may have social and medical implications. Nikolsky’s sign was found as less sensitive. Mucosal involvement was seen in pemphigus foliaceus patients.
Keywords: pemphigus vulgaris, foliaceus.
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