Title: Serum Level of Activin-A in Patients with Scarring and non Scarring Acne Vulgaris
Authors: Fatma M. Elesawy, Amany I. Mustafa, Walid A. Abdelhalim, Ghazwan M. Ismail
DOI: https://dx.doi.org/10.18535/jmscr/v7i10.125
Abstract
Background: Acne vulgaris (AV) is a common chronic inflammatory skin disease involving the pilosebaceous follicles characterized by comedones, papules, pustules, nodules and sometimes scars.
Objective: The aim of the present study is to evaluate serum level of activin-A in patients with scarring and non scarring acne vulgaris and assessment of its clinical significance.
Methods: A case control study that included 25 patients suffering from scarring acne vulgaris and 25 patients suffering from non scarring acne vulgaris., All studied subjects were tested for serum level of Activin-A.
Results: There was a statistically significant difference in serum level of activin-A between scarring and non-scarring acne vulgaris (P. value=0.039).
Conclusion: Evidence has been accumulated for an important role of activin in inflammation, tissue repair, and fibrosis. Thus, these findings strongly suggest that activin-A is a potent inducer of fibroblast activation and involved in the pathogenesis of scars.
Keywords: Acne Vulgaris, Activin-A.
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