Aims and Objectives: To study the prevalence of elevated serum total IgE levels and Absolute Eosinophil Count in Chronic Obstructive Pulmonary Disease (COPD) patients and its relation with GOLD staging.

Methods: This study is a cross sectional study conducted on 50 inpatients presented with symptoms of COPD in the department of medicine in RMMCH during the period from September 2017 to October 2019. The studied group was divided according to the GOLD staging and compared in demographic data, clinical data, spirometric data, chest x-ray findings, serum total IgE levels and Absolute Eosinophil Count (AEC).

Results: Out of the 50 patients enrolled in our study 84 % (n=42) of patients were found to have elevated serum IgE levels, and 58% (n=29) of patients were found to have elevated AEC levels. On comparing the serum IgE levels and Absolute Eosinophil Count with GOLD staging, there is a strong positive correlation between serum IgE, Absolute Eosinophil Count and GOLD staging, as the GOLD staging increases, the IgE and AEC also increases in a direct and linear fashion in our study subjects.

Conclusion: There was a high prevalence of elevated serum IgE levels and AEC in COPD patients. The mean serum total IgE levels and AEC increases as the GOLD stage increases.

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K.A. Vivek