The thyroid produces hormones (T3 and T4) that have many actions including metabolism, development, protein synthesis, and the regulation of many other important hormones. Any dysfunction in the thyroid can affect the production of thyroid hormones (T3 and T4) which can be linked to various pathologies throughout the body.

Method: A prospective cross-sectional study was conducted. All the 100 cases included in the study were classified into stages of CKD according to the glomerular filtration rate (GFR) calculated by Cockcroft–Gault formula. Staging of CKD was done according to the KDIGO guidelines.

Result: Among all the 100 cases, patients of Stage II were 10%, 16% patients were Stage III, 22% patients were Stage IV, and 52% of patients were Stage V. There were 33 CKD patients with SCH, 3 patients (9.09%) were Stage II CKD, 1 patient (3.03%) had Stage IIIA, 5 patients (15.15%) had Stage IIIB, 9 patients (27.27%) had Stage IV, and 15 patients (45.45%) had Stage V CKD. There were 20 CKD patients with overt hypothyroidism, of which 3 patients (5%) had Stage II CKD, 1 patient (5%) had Stage IIIA, 2 patients (10%) had Stage IIIB, 8 patients (40%) had Stage IV, and 8 patients (40%) had CKD Stage V.

Conclusion: Among them, 53% of patients had thyroid disorder. The most common thyroid hormone disorder was SCH (33%) followed by clinical hypothyroidism (20%), which was higher than that has been reported previously. The severity of thyroid dysfunction increases with progressive fall in GFR.

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Dr Arun Kumar

Medical Officer District Hospital, Jhanshi