Abstract
Objectives: The purpose of this study was to determine the serum level of biochemical parameters like serum Ferritin, Bilirubin, AST, ALT, ALP, total protein, albumin and CRP in pulmonary tuberculosis and its association with severity of disease.
Background: Present study is designed to estimate the biochemical parameters in pulmonary tuberculosis patients and healthy groups. The prevalence of pulmonary tuberculosis is higher in Hadoti region of Jhalawar (Rajasthan). Biochemical parameters are not only important for diagnosis purpose but also for prognosis and treatment.
Methods:50 patients of pulmonary tuberculosis and 50 healthy of control group were included and biochemical parameters i.e. serum Ferritin, Bilirubin, AST, ALT, ALP, total Protein, albumin and CRP were estimated by commercial kit method on fully Auto analyzer.
Results: Serum ferritin, bilirubin, AST, ALT, ALP and CRP were significantly higher (P<0.001).Total Protein, albumin were insignificant when the patients were compared with control group.
Conclusion: Determination of biochemical parameters is important in diagnosis and medical management of pulmonary tuberculosis.
Keywords: Pulmonary tuberculosis, Ferritin, C-reactive protein, AST, ALT, ALP, total protein, albumin.
References
- Benedicta d’Souza, Sulekha Sinha, Poornima Manjrekar and Viviand’Souza. Hyperferritinemia in Pulmonary tuberculosis. Indian Journal of Clinical Biochemistry. 2013.28(3) : 309-310.
- Hearnshaw’s, Thompson N, Mc Gilla. The epidemiology of Hyperferritinemia. World Journal of Gastroenterology. 2006.12: 5866-5869.
- Om Prakash Patidar, Ajay Kumar Bhargava, Deepak Gupta. Association of C-reactive protein and arterial hypertension. International Journal of Advances in Medicine. 2015;(2), 133-137.
- Priscilla Miranda-et-al, Leonardo Gil-santana, Marina G Oliveria, Eliene D.D., Mesquita Eeisengela Silva, Annerock Rauwerdink, Frank Coblens, Martha M Oliveria, Bruno B. Andrade, Afranio Kritski. Sustained elevated levels of C-reactive protein andferritin in pulmonary tuberculosis patients remaining culture positive upon treatment initiation phase one http://doi.org/10.1371/journal.pone.0175278.2017.
- Akari MZ, Fatima N ul Haque, Sheikh As, Bhatti MS. Liver function tests in patients of pulmonary tuberculosis using 4 different drug regimen. J. Ayub Medical College, Abbottabad. 2001,13(2):5-10.
- Carl A Burtis, Edward R Ashneood, David E Bruns. In Tietz textbook of clinical chemistry and molecular diagnostics. 5thed Elsevier 2012; Page524, 529, 574, 576, 673, 789, 993.
- Mohammad Shameem, Nazish Fatima, Asrar Ahmed, Abida Malik, Qayyum Hussain, correlation of serum C-reactive protein with disease severity in tuberculosis patients. Open Journal of respiratory disease 201. http://dx.doi.org/10.4236/ojrd 24014.95-100.
- Sandhya Mishra, PallaviTaparia, Dharamveer Yadav, Suresh Koolwal. Study of Iron metabolism in pulmonary tuberculosis patients International Journal of Health Sciences and Research 2018 8(3).
- Al-Omar IA, Oluboyede AO, Serum ferritin and other iron parameters in patients with pulmonary tuberculosis. Saudi Med J 2002; 23:244-6.
- Rai RR, Phadke MS. Plasma oxidant-antioxidant status in different respiratory disorders (2006) Indian J Coli Biochem (2006). 21(2):161-164 PMID. 23105636. DOI
- Abha Pandit, Abhay Kumar Pandey. Liver dysfunction in pulmonary tuberculosis patients on DOTS; A study and review Journal of Gastroenterology and Hepatology research (2016). 5(6), 2254-2260.
- Pratt DS, Kaplan MM (2000). Evaluation of abnormal liver enzyme results in asymptomatic patients N Engl J Med. 342(17) : 1266-1271.
- Abduller RLV Vaniev, Kaminskia GO, Vasileva FA, Komissarova OG. Evaluation of hepatic functionin new cases of pulmonary tuberculosis due to the use of standard chemotherapy regimen I and IIB. Probl Tuberk Bolezn Legk, PMAD. 2016 19382645. 57-61.
- E. Murthy, F Chatterjee. Pretreatment chest X-ray severity and its relation to bacterial burden in smear positive pulmonary tuberculosis (2018). BMC Medicine. http://toi.org/10.11.86/s1 2916.018-1053-3.
- Bhutto IA, Baba T, Mergy C, Juria Singhani V, Mc deod DS. Lutty GA C—reactive protein and complement factorsin aged human eyes and eyes with age related macular degeneration (2011) Br J. ophthalmology95. 1323-1330.
- Castellano A D, Munian A, Rodriguez Bano J et al. Factors associated with time to smear conversion in Active Pulmonary Tuberculosis. The International Journal of Tuberculosis and Lung Diseases. 2003; 7(5): 432-438.
- Huang HH, Yan HC, Han CL, Yu FC, Kao WY, Chen WT. Association of in-vitro oxidative stress, serum ferritin concentration and C-reactive protein in febrile emergency room patients. Clin Invest Med,2005; 28:48-54.
Corresponding Author
Rajendra Babu Mathur
Assistant Professor, Dept. of T.B. & Chest, Jhalawar Medical College, Jhalawar, Rajasthan, India
DOI: https://dx.doi.org/10.18535/jmscr/v7i10.69
