Title: Spectrum of Neuroendocrine Neoplasms – An Institutional Experience at a Tertiary Care Center
Authors: Mukesh Kumar, Mukta Meel, Deepika Hemrajani
DOI: https://dx.doi.org/10.18535/jmscr/v7i10.32
Abstract
Background: Neuroendocrine neoplasms (NENs) are relatively rare and heterogeneous tumor type, comprising ~2% of all malignancies. These tumours occur at various sites in the human body and are considered as one of the close differentials for many tumours. Various benign and malignant tumours undergo neuroendocrine differentiation. Its incidence is slightly increasing due to advanced imaging modalities.
The aim of the study is to study the spectrum of neuroendocrine tumours from various sites, their clinical presentation, histomorphological features with immunohistochemistry and review of literature.
Materials and Methods: This is a prospective study for a period of 1 year (Nov 2017-Oct 2018). Surgical resection specimens as well as biopsy were included in the study. Out of the total specimens received, 115 cases were of neuroendocrine tumours. Differential diagnosis of small round cell tumours also was considered and a panel of immunohistochemical markers were included to rule out them.
Results: Out of the 115 cases, 85 cases (73.9%) were benign lesions & 30 cases (26.1%) were malignant lesions. Female preponderance was noted. Peak incidence was seen in 41-60 years of age group.
Conclusion: Neuroendocrine tumours can occur anywhere in the body and it should be considered in one of the differential diagnosis of solid tumours. Diagnosis must be accurately made.
Keywords: Neuroendocrine Neoplasms, Heterogenous, Neuroendocrine Differentiation.
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