Background: Oral cancer is a major problem in the Indian subcontinent where it ranks among the top three types of cancer in the country and is eighth most common cancer worldwide. It is often preceded by precancerous or premalignant lesions, and conditions such as- Leukoplakia, Erythroplakia and Oral sub mucosal fibrosis.

Materials and Methods: A total of 142 patients who presented with clinical signs and symptoms of premalignant and malignant Stages of Oral Cancer were enrolled in the study. However, of which, 39 patients were excluded due to- patients expired (n=5); not reported for the next follow up (n=23); posted for radiation (n=2) and for surgery (n=9); during the study period. After exclusion of above 39 patients, 103 patients were eligible to include in the study, of them which, 88 were males and 15 were females.

Results: Socio demographic data of the patients:

In the present study, amongst 103 eligible patients, 88 (85.43%) were males and 15 (14.56%) were females. Majority of the patients were uneducated that constituted 70.87% (n=73) while educated patients was 29.12% (n=30). And also, 67.96% (n=70) of patients were identified from rural area and rest of 32.04% (n=33) from urban area.

Conclusion: In the present study, substantial improvement and decrease in disease severity was observed with selected (Lycopene) antioxidant therapy in different stages of oral cancer patients. Thus, antioxidants are overall favorable for early cases of oral premalignant lesions and conditions to cease and delay the disease progression.

Keywords: Anti oxidant, Lycopene, Oral cancer.

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Bachu Brahmani

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