Diabetes mellitus as a metabolic disorder invades with characterized hyperglycemia as well as glycosuria that if not treated properly can lead to the amputation of the arms and limbs. The increase in medi-care cost and the side effects that comes from the use of orthodox drugs has made scientists to look into phytomedicine, the use of plant herbs as an alternative for treatment modalities. Morus mesozygia Linn Stapf., was the medicinal plant chosen for this research study. The study evaluated the effects of Morus mesozygia Linn. Stapf., Leaves and Twigs on lipid profile and renal indices in Streptozotocin-Induced Diabetic Rats. A total of fifty (50) male albino rats were used for the study. Two different extracted solvents; aqueous, and ethanolic leaves extracts were used. The male albino rats for this study were induced with a single dose of 40mg/kg b.wt, streptozotocin in 0.1M of citrate buffer, pH 4.5 intraperitoneally. The diabetic male rats were those whose fasting blood glucose (FBG) were from 250mg/dl or 13mmol/L and above. TCHOL, TG & HDL-C were analyzed by enzymatic method, LDL-C by Frieldwald’s calculation. Electrolytes (K⁺, Na⁺, Cl^-, HCO₃^-) were analyzed by ion-selective electrode. A significant decrease (p<0.05) in TCHOL, TRIG, LDL and increased HDL levels when compared with those of the aqueous leaves and ethanolic leave extracts. The ethanolic leaves extract exhibited anti-hypercholesterolemic, anti-lipidemic activities more than the aqueous extract, this may be probably due to ethanol having a greater polarity index as well as exhibiting more components such as polyphenols, flavonoids,, tannins, saponins, alkaloids.

Keywords: Aqueous, Ethanolic Extracts, Morus mesozygia Linn. Stapf., Leaves, Lipid Profile, Renal Indices Streptozotocin-Induced,  Diabetic  Rats.

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M.T. Joshua

Department of Medical Laboratory Science, Rivers State University Port Harcourt