Objectives: The present study was performed to the assess the levels of thyroid profile and mineral profile in patients of schizophrenia & depression.

Material & Methods: 50 patients diagnosed for schizophrenia & 50 with depression visited the Out-patient Department (OPD) of Department of Psychiatric at Mahatma Gandhi Medical College & Hospital, Jaipur were enrolled for the study based on the predefined inclusion and exclusion criteria.

Observations: TSH levels (P=0.019) were significantly higher in the schizophrenia group whereas T₃ (P=0.004) &T₄ (P=0.001) values were significantly lower, serum Ca levels were lower (P= 0.000). serum Po₄ levels were significantly higher. (P=0.000) decrease serum Mg levels in schizophrenia group as compared to control group (P=0.003).

TSH levels were high in patient’s depression. (P=0.076) and less Serum T₃ (P=0.000) and T₄ (P=0.000) was observed in depression group. serum Ca and Mg levels were significantly lower in depression group (P=0.000) (P=0.020) respectively. the serum Po₄ levels were significantly higher. (P=0.004)

Conclusion: we concluded that in psychiatric disorder, thyroid hormones levels tend to be lower. This suggested hypo activity of thyroid gland. The study also reported decreased level of Ca & Mg and increased serum Po₄ levels. Derangement of the above minerals can lead to several complications. Thyroid hormones are responsible for regulation of the basal metabolic rate. Patients with psychiatric manifestations should be recommended screening for thyroid & mineral profile

Keywords: Schizophrenia, depression, hormonal , profile and mineral profile.

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Dr Sumit Kumar Tiwari

Senior Demonstrator, Department of Biochemistry, Mahatma Gandhi University of Medical Sciences & Technology, Jaipur Rajasthan