Title: Comparative Efficacy of Oral Tranexamic Acid and Trans-epidermal Delivery of Tranexamic Acid by Micro-Needling in Melasma
Authors: Mudita Gupta, Saru Thakur, Shikha Sharma, GR Tegta, Ghanshyam Verma
DOI: https://dx.doi.org/10.18535/jmscr/v7i8.73
Abstract
Background: Melasma is an acquired hyperpigmentary disorder of photo-exposed skin. It leads to lowered self-esteem. Treatment of melasma is not very rewarding and demands a multimodal approach. Tranexamic acid (TxA) acts as an inhibitor of melanin synthesis. There are multiple methods of delivering this drug to the site of melanization.
Aims: To compare the therapeutic efficacy and safety of tranexamic acid administered by microneedling and oral route in patients of melasma.
Methods: A prospective randomized study was conducted in 30 consecutive patients of melasma, who were enrolled into two groups; group A (received TxA by microneedling) and group B (oral TxA). The baseline details of melasma were recorded and MASI was recorded at 4,8 and 12 weeks.
Results: Females outnumbered males in a ratio of 4:1.There was no significant difference in the two groups on the basis of sex, age, duration of melasma, mean MASI score at baseline and pattern of melasma. Reduction in MASI score was more in oral TxA group but the difference was not statistically significant(5.89 vs 4.25). More than 50 % improvement was seen in 40 % patients in group B and 20% in group A.
Conclusion: Tranexamic acid is an effective treatment of melasma, the route of administration does not significantly alter the outcome.
Keywords: Melasma, tranexemic acid, oral, microneedling
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