Title: A Comparative Study of Onset Time and Intubating Conditions with Suxamethonium and Rocuronium Bromide– An Evaluation by Neuromuscular Monitoring
Authors: Vanlalhmangaaihi Hmar, Vanlalhruaii
DOI: https://dx.doi.org/10.18535/jmscr/v7i8.33
Abstract
Objective: To evaluate the onset of action of different doses of rocuronium bromide and suxamethonium and to observe the ideal intubating conditions of the drugs belonging to different groups.
Methods: Ninety adult patients were randomly allocated to one of the three groups, to receive either inj.suxamethonium 1.5mg/kg (group-I) or inj.rocuronium bromide 0.6mg/kg (group-II) or inj.rocuronium bromide 0.9mg/kg (group-III).
Results: The results showed that the onset time for suxamethonium group was 66secs compared to 86.5secs of the rocuronium 0.6mg/kg group and 59secs with the rocuronium 0.9mg/kg group. The intubating condition scores were 8.53 each for suxamethonium group and rocuronium 0.6mg/kg group respectively and 8.70 for rocuronium 0.9mg/kg group.
Conclusion: There was apparent difference in the onset time of the drugs among the three groups but all the three groups have similar intubating conditions. Suxamethonium 1.5mg/kg has faster onset of action than rocuronium at a dose of 0.6mg/kg. Rocuronium at a dose of 0.9mg/kg is the most suitable dose of rocuronium for endotracheal intubation and this is the dose to be recommended for rapid sequence intubation, an alternative to suxamethonium in conditions where the latter is contraindicated or hazardous.
Keywords: Rocuronium bromide, Suxamethonium, intubation.
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