Various exogenous and endogenous stimuli incite a complex reaction in vascularized connective tissue called inflammation. Non steroidal anti inflammatory drugs are used to reduce inflammation. Preferential COX-2 inhibitors namely diclofenac and aceclofenac was taken for my present work and anti inflammatory effect was compared with control and with each other. Student-t-test-was done to compare result. It was found that inflammation varied significantly across the three groups (P=.000) Compared to control, inflammation was less in both diclofenac and aceclofenac (P=.00). Reduction of inflammation with diclofenac was less. In comparision to aceclofenac at end. Aceclofenac is more efficacious than diclofenac.

Keywords: Aceclofenac, diclofenac, Anti inflammatory effect.

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Dr Amit Kumar Jha

Associate Professor, Department of Pharmacology VIMS, Pawapuri, Bihar, India