Title: A Comparative Study of Clinical Profile of Dengue in Patients with and without Diabetes Mellitus Admitted in a Tertiary Care Centre in Rural South Kerala
Authors: Dr H Poornima, Dr Arathi N
DOI: https://dx.doi.org/10.18535/jmscr/v7i7.92
Abstract
Background: Dengue is one of the most common infection in the tropical countries. Comorbidities, especially Diabetes is known to influence the outcome of patients with Dengue fever.
Objectives: To study the clinical profile of patients with dengue and to identify the role of Diabetes mellitus in the development of sever dengue.
Methods: Observational study on 342 patients admitted with a diagnosis of Dengue fever. Patients were admitted and managed as per the institutional protocol. The patients were studied during the entire hospital stay and was observed for the development of complications like hemorrhage or shock. The differences in occurrence of complications among diabetics and non diabetics were compared.
Results: Complications like Dengue Hemorrhagic fever, Shock and mortality were high among diabetics when compared to non diabetics.
Conclusions: Diabetic patients admitted with dengue requires more vigilant monitoring for development of complications.
References
- World Health Organisation, Dengue guidelines for diagnosis, treatment, prevention and control. Geneva: World Health Organisation: 2009
- Murray NE, Quam MB, Wilder- Smith A. Epidemiology of Dengue: Past, present and future prospects. Clin Epidemiol 2013; 5: 299-309.
- World Health Organisation, Dengue hemorrhagic fever: diagnosis, treatment, prevention and control. 2nd Geneva: world health organization 1997.
- Lee IK, Liu JW, Yang KD. Fatal dengue hemorrhagic fever in adults: emphasizing the evolutionary pre fatal clinical and laboratory manifestations. PLoS Neglected Trop Dis 2012: 6;e 1532
- Tsai Cy, Lee IK, Lee CH, Yang KD, Liu JW. Comparisons of dengue illness classified based on the 1997 and 2009 World Health Organisation dengue classification schemes. J Microbiol Immunol Infect 2013; 46:271e 81.
- Figueiredo MA, Rodrigues LC, Barreto ML, Lima JW, Costa MC, MOrato V et al. Allergies and diabetes as risk factors for Dengue Hemorrhagic fever: Results of a cse control study. PLoS Neglected Tropical Disease. 2010;4: e699
- Pang J, Salim A, Lee VJ, Hibberd ML, Chia KS, Leo YS et al. diabetes with hypertension as a risk factor for adult dengue hemorrhagic fever in a predominantly serotype 2 epimdemic: A case contro; study: PLoS Neglected Tropical Disease. 2012;6: e 1641
- Limonta D, Torres G, Capo V, Guzma n MG. apoptosis, vascular leakage and increased risk of severe dengue in a type 2 diabetes mellitus patient. Diabetes Vasc Dis Res 2008;5: 2 13e 4
- Htun NS, Odermatt P, Eze IC et al. Is diabetes a risk factor for a severe clinical presentation of dengue? Review and mta analysis. PLoS Neglected tropical disease. 2015;9:e0003741
- Shih CJ et al. Association between the use of oral anti diabetic agents and the risk of sepsis: A nested case-control study. Scientific reports 2015:5;15260.